Assessment of relationships between novel inflammatory markers and presence and severity of preeclampsia: Epicardial fat thickness, pentraxin-3, and neutrophil-to-lymphocyte ratio

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dc.authoridCOSKUN, Ebru INCI/0000-0003-4402-3725
dc.authoridDincgez, Burcu/0000-0002-2697-7501;
dc.authorwosidCOSKUN, Ebru INCI/ABI-8238-2020
dc.authorwosidDincgez, Burcu/AAH-5248-2020
dc.authorwosiderturk, mehmet/AAL-3597-2020
dc.contributor.authorCakmak, Huseyin Altug
dc.contributor.authorCakmak, Burcu Dincgez
dc.contributor.authorYayla, Cigdem Abide
dc.contributor.authorCoskun, Ebru Inci
dc.contributor.authorErturk, Mehmet
dc.contributor.authorKeles, Ibrahim
dc.date.accessioned2024-08-04T20:43:11Z
dc.date.available2024-08-04T20:43:11Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate the relation of three new inflammatory markers with presence and severity of preeclampsia and to compare the predictive values of all markers for presence of this setting.Methods: In this study, a total of 100 consecutive pregnants with a diagnosis of preeclampsia and 40 healthy pregnants between October 2014 and April 2015 were included. Epicardial fat tissue was calculated by two-dimensional transthoracic echocardiography, and pentraxin-3 and neutrophil-to-lymphocyte ratio were measured by using an enzyme-linked immunosorbent assay method and routine blood count analysis, respectively.Results: Epicardial fat thickness (p<0.001), pentraxin-3 (p<0.001), and neutrophil-to-lymphocyte ratio (p<0.001) were found to be significantly increased in the preeclampsia as compared to the healthy pregnants. Furthermore, epicardial fat thickness (p=0.002), pentraxin-3 (p<0.001), and neutrophil-to-lymphocyte ratio (p<0.001) were significantly elevated in the severe preeclampsia compared to mild preeclampsia. In the multivariate analysis, epicardial fat thickness (p=0.013), pentraxin-3 (p=0.04), and neutrophil-to-lymphocyte ratio (p<0.001) were found as significant independent predictors of presence of preeclampsia after adjusting for other risk factors.Conclusion: Epicardial fat thickness, neutrophil-to-lymphocyte ratio, and pentraxin-3 are important markers that provide an additional information beyond that provided by conventional methods in predicting presence and severity of preeclampsia.en_US
dc.identifier.doi10.1080/10641955.2017.1321016
dc.identifier.endpage239en_US
dc.identifier.issn1064-1955
dc.identifier.issn1525-6065
dc.identifier.issue3en_US
dc.identifier.pmid28569615en_US
dc.identifier.scopus2-s2.0-85020170146en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage233en_US
dc.identifier.urihttps://doi.org/10.1080/10641955.2017.1321016
dc.identifier.urihttps://hdl.handle.net/11616/97840
dc.identifier.volume36en_US
dc.identifier.wosWOS:000410904800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofHypertension in Pregnancyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpicardial fat thicknessen_US
dc.subjectneutrophil-to-lymphocyte ratioen_US
dc.subjectpentraxin-3en_US
dc.subjectpreeclampsiaen_US
dc.titleAssessment of relationships between novel inflammatory markers and presence and severity of preeclampsia: Epicardial fat thickness, pentraxin-3, and neutrophil-to-lymphocyte ratioen_US
dc.typeArticleen_US

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