2-Hydroxyethyl substituted NHC precursors: Synthesis, characterization, crystal structure and carbonic anhydrase, ?-glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory properties

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dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridKARABIYIK, Hasan/0000-0001-7894-6646
dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidGulcin, ilhami/F-1428-2014
dc.authorwosidKARABIYIK, Hasan/P-2879-2019
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.authorwosidBarut Celepci, Duygu/M-6189-2017
dc.authorwosidTaslimi, Parham/AAL-2788-2020
dc.contributor.authorErdemir, Fatos
dc.contributor.authorCelepci, Duygu Barut
dc.contributor.authorAktas, Aydin
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGok, Yetkin
dc.contributor.authorKarabiyik, Hasan
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-08-04T20:44:07Z
dc.date.available2024-08-04T20:44:07Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study contains novel a serie synthesis of N-heterocyclic carbene (NHC) precursors that 2-hydroxyethyl substituted. The NHC precursors have been prepared from 1-(2-hydroxyethyl)benzimidazole and alkyl halides. The novel NHC precursors have been characterized by using H-1 NMR, C-13 NMR, FTIR spectroscopy and elemental analysis techniques. Molecular and crystal structures of 2a, 2d, 2e, 2f and 2g were obtained with single-crystal X-ray diffraction studies. These novel NHC precursor's derivatives effectively inhibited the a-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). Inhibition constant (K-i) were found in the range of 0.30-9.22 nM for alpha-glycosidase, 13.90-41.46 nM for hCA I, 12.82-49.95 nM for hCA II, 145.82-882.01 nM for BChE, and 280.92-1370.01 nM for AChE, respectively. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipDokuz Eylul University [2010.KB.FEN.13]; Inonu University Research Fund [I.U.B.A.P.2016/125]en_US
dc.description.sponsorshipThe authors acknowledge Dokuz Eylul University for the use of the Oxford Rigaku Xcalibur Eos Diffractometer (purchased under University Research Grant No: 2010.KB.FEN.13). This work was financially supported by Inonu University Research Fund (I.U.B.A.P.2016/125).en_US
dc.identifier.doi10.1016/j.molstruc.2017.11.079
dc.identifier.endpage806en_US
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85034842015en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage797en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2017.11.079
dc.identifier.urihttps://hdl.handle.net/11616/98037
dc.identifier.volume1155en_US
dc.identifier.wosWOS:000424717800084en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-heterocyclic carbenesen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectCholinesteraseen_US
dc.subjectalpha-Glycosidaseen_US
dc.subjectX-ray diffractionen_US
dc.title2-Hydroxyethyl substituted NHC precursors: Synthesis, characterization, crystal structure and carbonic anhydrase, ?-glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory propertiesen_US
dc.typeArticleen_US

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