Early- and late-state subacute sclerosing panencephalitis: Chemical shift imaging and single-voxel MR spectroscopy

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dc.authoridKutlu, Ramazan/0000-0001-7941-7025
dc.authoridAslan, Mehmet/0000-0001-5710-6592
dc.authoridYakıncı, Mehmet Cengiz/0000-0001-5930-4269
dc.authoridSigirci, Ahmet/0000-0001-9221-0002;
dc.authorwosidKutlu, Ramazan/B-1624-2016
dc.authorwosidAslan, Mehmet/AEL-7823-2022
dc.authorwosidYakıncı, Mehmet Cengiz/ABI-7519-2020
dc.authorwosidSigirci, Ahmet/ABG-7387-2020
dc.authorwosidSaraç, Kaya/ABI-1091-2020
dc.contributor.authorAlkan, A
dc.contributor.authorSarac, K
dc.contributor.authorKutlu, R
dc.contributor.authorYakinci, C
dc.contributor.authorSigirci, A
dc.contributor.authorAslan, M
dc.contributor.authorBaysal, T
dc.date.accessioned2024-08-04T20:13:15Z
dc.date.available2024-08-04T20:13:15Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND AND PURPOSE: Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease. Our aim was to determine the metabolic abnormalities of brain in early- and late-stage SSPE by using MR spectroscopy and to assess areas of involvement in the early stages when MR imaging findings were normal. METHODS: Children with stage II (n = 3) or III (n = 3) SSPE and 10 healthy, age-matched children underwent MR imaging, multivoxel MR spectroscopy, and short-echo single-voxel MR spectroscopy (SVS). Areas of involvement in the brain were determined with chemical shift imaging. For SVS, 2 x 2 x 2-cm voxels were placed in the frontal subcortical white matter (FSWM) and parieto-occipital white matter (POWM). N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, myo-inositol (Ins)/Cr, and NAA/Cho ratios were calculated. RESULTS: Comparisons of NAA/Cr, Cho/Cr, Ins/Cr and NAA/Cho ratios between patients and control subjects showed significant differences in FSWM and POWM (P <.0l). In patients with SSPE, NAA/Cr ratios in POWM were significantly less than those in FSWM (P <.0l). NAA/Cr ratios in patients with stage II SSPE and those in the control group were not significantly different; this may reflect the absence of neuronal loss. Decreased NAA/Cr, increased Cho/Cr and Ins/Cr ratios, and increased lactate and lipid peaks were found in patients with stage III SSPE. CONCLUSION: MR spectroscopy showed findings suggestive of inflammation in stage II and findings of demyelination, gliosis, cellular necrosis, and anaerobic metabolism in stage III. MR spectroscopy could be a promising technique for early diagnosis and treatment planning in cases of SSPE.en_US
dc.identifier.endpage506en_US
dc.identifier.issn0195-6108
dc.identifier.issue3en_US
dc.identifier.pmid12637304en_US
dc.identifier.scopus2-s2.0-0037346269en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage501en_US
dc.identifier.urihttps://hdl.handle.net/11616/93494
dc.identifier.volume24en_US
dc.identifier.wosWOS:000181744500036en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Soc Neuroradiologyen_US
dc.relation.ispartofAmerican Journal of Neuroradiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntraventricular Alpha-Interferonen_US
dc.titleEarly- and late-state subacute sclerosing panencephalitis: Chemical shift imaging and single-voxel MR spectroscopyen_US
dc.typeArticleen_US

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