Acute Amitriptyline Poisoning in Childhood: Experience of a Single Center
| dc.contributor.author | Ozdemir, Ramazan | |
| dc.contributor.author | Bayrakcı, Benan | |
| dc.contributor.author | Tekşam, Ozlem | |
| dc.date.accessioned | 2014-08-06T06:47:02Z | |
| dc.date.available | 2014-08-06T06:47:02Z | |
| dc.date.issued | 2013 | |
| dc.description | İnönü Üniversitesi Tıp Fakültesi Dergisi, 2013. | en_US |
| dc.description.abstract | Objective: High-dose amitriptyline is a common cause of childhood poisoning. The aim of this study was to evaluate the demographic and clinical characteristics of 126 children who presented with amitriptyline poisoning. Material and Methods: The medical records of children who were admitted to the Pediatric Intensive Care Unit for amitriptyline poisoning between January 1986 and March 2011 were retrospectively evaluated. Results: High-dose amitriptyline is a common cause of childhood poisoning. An increase in the number of cases of amitriptyline poisoning was observed in recent years, with 62.7% of all cases being accidental whereas 37.3% of cases were attempted suicides. The mean age of accidental cases of poisoning was 2.9±1.4 years compared to 14.2±1.9 years for suicidal cases (p<0.01). Patients who accidentally ingested amitriptyline presented to a health care facility in a shorter period than those who took the drug with suicidal intent (respectively 2.4±2 hours vs. 4.2±4.3 hours; p<0.01). In 78.3% of cases, the drug was stored in place easily accessible to children. While 37.3% of patients took the drug at toxic doses, in 47.6% of patients the amount of amitriptyline ingested was below the toxic dose. Seventy-one percent of patients had neurological symptoms on presentation. Gastric lavage was the most commonly utilized treatment modality (78% all of cases). Only one patient who had accidentally consumed the drug at a dose of 15mg/kg died. Conclusion: There is a dire need for reforms in political, industrial and public health policies regarding the packaging and storage of medications which are a common cause of accidental drug poisoning with potentially severe consequences. | en_US |
| dc.identifier.citation | Ramazan Ozdemir, Benan Bayrakcı, Ozlem Tekşam.(2013). Açık Dergisi Sistemleri (ADS) İnönü Üniversitesi Tıp Fakültesi Dergisi. | en_US |
| dc.identifier.uri | http://www.totmdergisi.org/articles/2013/volume20/issue2/2013_20_2_2.pdf | |
| dc.identifier.uri | https://hdl.handle.net/11616/65 | |
| dc.language.iso | en | en_US |
| dc.publisher | İnönü Üniversitesi Tıp Fakültesi Dergisi | en_US |
| dc.subject | Amitriptyline | en_US |
| dc.subject | Poisoning | en_US |
| dc.subject | Plasma Exchange | en_US |
| dc.title | Acute Amitriptyline Poisoning in Childhood: Experience of a Single Center | en_US |
| dc.type | Article | en_US |
