Substituted N-heterocyclic carbene PEPPSI-type palladium complexes with different N-coordinated ligands: Involvement in the direct C-H bond activation of heteroarenes derivatives with aryl bromide and their antimicrobial, anti-inflammatory and antioxidant activities

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dc.authoridÖzdemir, Namık/0000-0003-3371-9874
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authorwosidÖzdemir, Namık/J-6434-2015
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidMansour, Lamjed/U-3028-2017
dc.contributor.authorSlimani, I
dc.contributor.authorBoubakri, L.
dc.contributor.authorOzdemir, N.
dc.contributor.authorMansour, L.
dc.contributor.authorOzdemir, I
dc.contributor.authorGurbuz, N.
dc.contributor.authorYasar, S.
dc.date.accessioned2024-08-04T20:51:38Z
dc.date.available2024-08-04T20:51:38Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study new benzimidazolium salt as N-heterocyclic carbene precursors and their related new PEPPSI-Pd (II)-N-heterocyclic carbene (NHC) complexes 3a-e were prepared and caracterized. The structures of all compounds have been characterized by H-1 NMR, C-13 NMR, and IR spectroscopy, as well as elemental analysis techniques and Direct analysis in real time (DART)-time-of-flight mass spectrometry (TOF-MS), which support the proposed structures. Further confirmations of structural details were provided by a single-crystal X-ray. A single crystal of PEPPSI-Pd(II)-N-heterocyclic carbene (NHC) complex 3c shows that the coordination geometry around Pd slightly distorted square-planar geometry. Next, the PEPPSI-Pd(II)-N-heterocyclic carbene (NHC) complexes 3a-e were used as catalysts in the direct C-5-arylation of 2-acetyl furan and 2-acetylthiophene with various aryl bromides. These complexes exhibited moderate to high catalytic activities and gave C-H activation selectively at the C-5-position. Further, PEPPSI-Pd(II)-N-heterocyclic carbene (NHC) complexes 3a-e have been evaluated for their potential antibacterial properties against a panel of bacterial strains namely, Micrococcus luteus, Listeria monocytogenes, Salmonella Typhimurium, Staphylococcus aureus, candida albican and pseudomonas aeruginosa. In addition; these new PEPPSI-Pd(II)-N-heterocyclic carbene (NHC) complexes 3a-e were investigated for anti-oxidant activities by super oxide radical; DPPH (2,2-Diphenyl-1-picrylhydrazyl); and hydroxyl radical scavenging assays; in which most of them displayed significant antioxidant activities. Furthermore; PEPPSI-Pd(II)-N-heterocyclic carbene (NHC) complexes 3a-e were evaluated for anti-inflammatory activity by indirect haemolytic and lipoxygenase inhibition assays and revealed good activity.en_US
dc.description.sponsorshipKing Saud University (Riyadh, Saudi Arabia) [RSP2021/75]en_US
dc.description.sponsorshipThis work was supported by the Research Supporting Project (RSP2021/75), King Saud University (Riyadh, Saudi Arabia).en_US
dc.identifier.doi10.1016/j.ica.2021.120747
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-85124037500en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2021.120747
dc.identifier.urihttps://hdl.handle.net/11616/100460
dc.identifier.volume532en_US
dc.identifier.wosWOS:000741963600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofInorganica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbeneen_US
dc.subjectPEPPSI-type palladium-NHC complexesen_US
dc.subjectDirect arylationen_US
dc.subjectN-Heterocyclic carbene benzimidazolium saltsen_US
dc.subjectAntimicrobialen_US
dc.subjectAntioxidant and anti-inflammatory activitiesen_US
dc.titleSubstituted N-heterocyclic carbene PEPPSI-type palladium complexes with different N-coordinated ligands: Involvement in the direct C-H bond activation of heteroarenes derivatives with aryl bromide and their antimicrobial, anti-inflammatory and antioxidant activitiesen_US
dc.typeArticleen_US

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