Adrenomedullin and nitrite levels in children with Bartter syndrome

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dc.authoridKutlu, Nurettin Onur/0000-0002-3306-6570
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridBalat, Ayse/0000-0002-8904-1348
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authorwosidcekmen, mustafa baki/G-6122-2011
dc.authorwosidKutlu, Nurettin Onur/AAW-6196-2021
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidBalat, Ayse/JOZ-8426-2023
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.contributor.authorBalat, A
dc.contributor.authorÇekmen, M
dc.contributor.authorYürekli, M
dc.contributor.authorKutlu, O
dc.contributor.authorIslek, I
dc.contributor.authorSönmezgöz, E
dc.contributor.authorÇakir, M
dc.date.accessioned2024-08-04T20:12:07Z
dc.date.available2024-08-04T20:12:07Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractChildren with Bartter syndrome have lower than normal vascular reactivity with normotension in spite of biochemical and hormonal abnormalities which are typical of hypertension. Nitric oxide (NO) is a potent endogenous vasodilator, and plays an important role in the control of vascular tone. Adrenomedullin (AM) is a novel hypotensive peptide originally isolated from human pheochromocytoma. The possible role of NO and PLM in maintaining this reduced vascular reactivity was examined by studying plasma and urinary nitrite, a stable metabolite of NO, and AM levels in ten children with Bartter syndrome, ten healthy controls, and five children with hypokalemia of causes other than Bartter syndrome (pseudo-Bartter). Urinary excretion of nitrite (mu mol/mg urinary creatinine) was 8.9.+/-1.2 in children with Bartter syndrome, 4.7.+/-0.9 in healthy controls, and 2.9.+/-0.8 in pseudo-Bartter (P<0.05). Plasma nitrite levels (mol/l) were 101.9+/-23.4, 59.9+/-14.7, and 65.0+/-29.7, respectively (P>0.05), in the three groups. Urinary excretion of AM (pmol/mg urinary creatinine) was 187+/-40, 65+/-10, and 160+/-50, respectively (P<0.05), in the three groups. Plasma AM levels were 47.4+/-1.8, 39.9+/-5.9, and 42.4+/-3.9, respectively (P>0.05), in the three groups. The same parameters were repeated in the two groups of controls and in the Bartter patients in the 6th month of therapy. Urinary nitrite and AM levels were still higher in the Bartter patients than in the other groups. We conclude that in Bartter syndrome the increased NO production may be responsible for the reduced vascular response of the disease. Initially, increased levels of AM in Bartter syndrome and pseudo-Bartter may be a compensatory response to acute hypokalemia; however, continuation of a high level of urinary excretion of AM in children with Bartter syndrome may suggest also the possible role of AM in the reduced vascular response of the disease.en_US
dc.identifier.doi10.1007/s004670000474
dc.identifier.endpage270en_US
dc.identifier.issn0931-041X
dc.identifier.issue3-4en_US
dc.identifier.pmid11149123en_US
dc.identifier.scopus2-s2.0-0033635374en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage266en_US
dc.identifier.urihttps://doi.org/10.1007/s004670000474
dc.identifier.urihttps://hdl.handle.net/11616/93206
dc.identifier.volume15en_US
dc.identifier.wosWOS:000165758800022en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectBartter syndromeen_US
dc.subjectnitric oxideen_US
dc.titleAdrenomedullin and nitrite levels in children with Bartter syndromeen_US
dc.typeArticleen_US

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