Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line

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dc.contributor.authorAlagöz, Mehmet
dc.contributor.authorÖzdemir, Zeynep
dc.contributor.authorHepokur, Ceylan
dc.contributor.authorKarakurt, Arzu
dc.date.accessioned2024-08-04T19:53:21Z
dc.date.available2024-08-04T19:53:21Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCancer, a disease defined by rapid proliferation of cells, still remains one of the most feared diseases of the modern world. Many structurally different anti-carcinogenic drugs are used in several tumor types such as bladder, colon, ovary, breast, head and neck, testis, lung and prostate cancer. In this study, cytotoxic effects of the compounds with different linkers (ketone, oxime, alcohol, chlorine) between pyrazole and trifluoromethyl on MCF-7 (human breast adenocarcinoma), MDA-MB-231 (human breast adenocarcinoma), and HCT-116 (human colon cancer) cell lines were investigated. Compound a1 was observed to be the most potent compound with IC50 values of 5.84±0.76, 5.01±0.32, 5.57±0.02 µg.ml-1 against these cell lines, respectively. It was found that all compounds were very effective against all the tested cancer cell lines.en_US
dc.identifier.doi10.5455/medscience.2022.04.085
dc.identifier.endpage1216en_US
dc.identifier.issn2147-0634
dc.identifier.issue3en_US
dc.identifier.startpage1212en_US
dc.identifier.trdizinid1131323en_US
dc.identifier.urihttps://doi.org/10.5455/medscience.2022.04.085
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1131323
dc.identifier.urihttps://hdl.handle.net/11616/89683
dc.identifier.volume11en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleCytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell lineen_US
dc.typeArticleen_US

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