The Effect of Selenium on Ischemia-Reperfusion Injury: An Experimental Study on a Transverse Rectus Abdominis Musculocutaneous Flap Model

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridErdemli, Erman/0000-0003-4596-7525
dc.authoridTenekeci, Goktekin/0000-0002-5777-4301
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidErdemli, Erman/ABI-8193-2020
dc.contributor.authorTenekeci, Goktekin
dc.contributor.authorBilen, Bilge Turk
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorSahin, Nurhan
dc.contributor.authorBulam, Nazire
dc.contributor.authorErdemli, Mehmet Erman
dc.date.accessioned2024-08-04T20:41:29Z
dc.date.available2024-08-04T20:41:29Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground:The aim of this study is to investigate effects of selenium and enlighten the possible mechanism of action in a rat transverse musculocutaneous flap model following ischemia-reperfusion injury.Materials and Methods:In this study, an experimental model, which mimicked free tissue transfer, was applied. Twenty-four male Wistar Albino rats were divided into a control group (N=12), and a selenium treated group (N=12). A superiorly based transverse rectus abdominis musculocutaneous (TRAM) flap was elevated and an ischemic insult for 4 hours was given. In selenium treated group (Group 2), sodium selenite (0.625mg/kg) was injected intraperitoneally (i.p), 2 hours before the induction of ischemia. Six rats from each group were sacrificed at 24 hours after the operation and malonyldialdehyde (MDA), nitric oxide (NO), and glutathione (GSH) levels were measured biochemically, whereas the intensity of neutrophil infiltration was evaluated. For the rest of the rats in Group 2, sodium selenite was injected at the same dose everyday to the postoperative 10th day, in which the remaining 6 rats from each group were sacrificed. On postoperative 10th day, flap viability was assessed along with the evaluation of intensity of neovascularization.Results:In Group 1, MDA levels were higher significantly (P<0.05) when compared with Group 2. No statistical difference, however, was found for NO (P>0.05), and GSH (P>0.05) levels among Group 1 and 2. Neutrophil infiltration was more intense in Group 1, when compared with Group 2 whereas neovascularization was more abundant in samples of Group 2. Group 2 shows higher average flap surface areas when compared with Group 1 (P<0.05).Discussion:The results of this study demonstrated the preventive effect of selenium against ischemia-reperfusion injury by reducing tissue necrosis in muscle flaps possibly by decreasing MDA, increasing neovascularization, and decreasing neutrophil infiltration, thus suppressing inflammation.en_US
dc.identifier.doi10.1097/SCS.0000000000002178
dc.identifier.endpage246en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue1en_US
dc.identifier.pmid26674890en_US
dc.identifier.scopus2-s2.0-84957563112en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage242en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000002178
dc.identifier.urihttps://hdl.handle.net/11616/97159
dc.identifier.volume27en_US
dc.identifier.wosWOS:000370075700056en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlutathioneen_US
dc.subjectmalonyldialdehydeen_US
dc.subjectmusculocutaneous flapen_US
dc.subjectnitric oxideen_US
dc.subjectseleniumen_US
dc.titleThe Effect of Selenium on Ischemia-Reperfusion Injury: An Experimental Study on a Transverse Rectus Abdominis Musculocutaneous Flap Modelen_US
dc.typeArticleen_US

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