Evaluating Multiple Biochemical Markers in Xenopus laevis Tadpoles Exposed to the Pesticides Thiacloprid and Trifloxystrobin in Single and Mixed Forms

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dc.authoridUÇKUN, Miraç/0000-0002-9018-8515;
dc.authorwosidUÇKUN, Miraç/ABC-4209-2021
dc.authorwosidMiraç, Uçkun/ABG-5824-2021
dc.authorwosidOZMEN, MURAT/A-4874-2009
dc.contributor.authorUckun, Mirac
dc.contributor.authorOzmen, Murat
dc.date.accessioned2024-08-04T20:50:34Z
dc.date.available2024-08-04T20:50:34Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPesticide exposure is thought to be one of the common reasons for the decline in amphibian populations, a phenomenon that is a major threat to global biodiversity. Although the single effects of pesticides on amphibians have been well studied, the effects of mixtures are not well known. The present study aimed to evaluate the acute toxicity of the insecticide thiacloprid and the fungicide trifloxystrobin on early developmental stages of Xenopus laevis using various biochemical markers (glutathione S-transferase, glutathione reductase, acetylcholinesterase, carboxylesterase, glutathione peroxidase, catalase, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, Na+K+-adenosine triphosphatase [ATPase], Ca2+-ATPase, Mg2+-ATPase, and total ATPase). The median lethal concentrations (LC50s) of thiacloprid and trifloxystrobin were determined to be 3.41 and 0.09 mg a.i. L-1, respectively. Tadpoles were exposed to the LC50, LC50/2, LC50/10, LC50/20, LC50/50, and LC50/100 of these pesticides. Both pesticides significantly affected (inhibited/activated) the biomarkers even at low concentrations. The pesticides showed a synergistic effect when applied as a mixture and altered the biomarkers more than when applied individually. In conclusion, we can assume that tadpoles are threatened by these pesticides even at environmentally relevant concentrations. Our findings provide important data to guide management of the ecotoxicological effects of these pesticides on nontarget amphibians. Environ Toxicol Chem 2021;00:1-15. (c) 2021 SETACen_US
dc.description.sponsorshipScientific Research Fund of the Inonu University (I.U. BAPB project) [2010/116]en_US
dc.description.sponsorshipThe present study was supported by the Scientific Research Fund of the Inonu University (I.U. BAPB project 2010/116).en_US
dc.identifier.doi10.1002/etc.5158
dc.identifier.endpage2860en_US
dc.identifier.issn0730-7268
dc.identifier.issn1552-8618
dc.identifier.issue10en_US
dc.identifier.pmid34255878en_US
dc.identifier.scopus2-s2.0-85112857832en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2846en_US
dc.identifier.urihttps://doi.org/10.1002/etc.5158
dc.identifier.urihttps://hdl.handle.net/11616/100142
dc.identifier.volume40en_US
dc.identifier.wosWOS:000685716100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEnvironmental Toxicology and Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInsecticideen_US
dc.subjectFungicideen_US
dc.subjectAmphibianen_US
dc.subjectEnzymesen_US
dc.subjectAcute toxicityen_US
dc.titleEvaluating Multiple Biochemical Markers in Xenopus laevis Tadpoles Exposed to the Pesticides Thiacloprid and Trifloxystrobin in Single and Mixed Formsen_US
dc.typeArticleen_US

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