Synthesis, cytotoxic and antimicrobial activities of novel cobalt and zinc complexes of benzimidazole derivatives

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dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486
dc.authoridYesilada, Ozfer/0000-0003-0038-6575
dc.authoridYılmaz, Ülkü/0000-0002-2806-4781
dc.authoridYilmaz, Omer/0000-0002-0962-2725
dc.authoridYilmaz, Ozgur/0000-0001-6489-761X
dc.authoridBaran, Yusuf/0000-0002-1056-4673
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.authorwosidApohan, Elif/AAA-5142-2021
dc.authorwosidYesilada, Ozfer/ABI-1335-2020
dc.authorwosidYılmaz, Ülkü/AAA-7545-2020
dc.authorwosidYilmaz, Omer/KHZ-8294-2024
dc.contributor.authorApohan, Elif
dc.contributor.authorYilmaz, Ulku
dc.contributor.authorYilmaz, Ozgur
dc.contributor.authorSerindag, Ayfer
dc.contributor.authorKucukbay, Hasan
dc.contributor.authorYesilada, Ozfer
dc.contributor.authorBaran, Yusuf
dc.date.accessioned2024-08-04T20:42:50Z
dc.date.available2024-08-04T20:42:50Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study fourteen novel cobalt (II) or zinc (II) complexes of benzimidazoles were synthesized from the 1-(4-substitutedbenzyl)-1H-benzimidazoles and CoCl2.6H(2)O or ZnCl2. Cytotoxic activities of novel complexes were investigated against lung cancer cells (A549) and BEAS-2B. Three of the examined compounds (1, 4 and 5) showed high cytotoxic activity against A549. While the IC50 of the cisplatin was 2.56 pg/mL for A549 cells at 72 h, the IC50 values of compounds 1, 4 and 5 were 1.97, 1.87 and 1.9 mu g/mL, respectively. IC50 values of these compounds for BEAS-2B cells were higher than the IC50 values for A549. While the IC50 values for BEAS-2B cells were 59.8, 24.5 and 32.67 mu g/mL, respectively, the IC50 of the cisplatin was determined as 2.53 pgimL in the present work. Three of the compounds have also high antimicrobial activity against all the microorganisms used. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council in Turkey (TUBITAK) [113Z647]en_US
dc.description.sponsorshipThe authors would like to thank the financial support from The Scientific and Technological Research Council in Turkey (TUBITAK) (Grant no: 113Z647). We would like to thank Assist. Prof. Harika Gozukara Bag (Inonu University, Medical Faculty, Department of Biostatistics, Malatya/Turkey) and Ayla Burcin Asutay (Yeditepe University, Department of Genetics and Bioengineering, Istanbul/Turkey) for helping about statistical analysis and sending the A549 cells, respectively.en_US
dc.identifier.doi10.1016/j.jorganchem.2016.11.020
dc.identifier.endpage58en_US
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-84997190840en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage52en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2016.11.020
dc.identifier.urihttps://hdl.handle.net/11616/97597
dc.identifier.volume828en_US
dc.identifier.wosWOS:000392557400007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBenzimidazole complexesen_US
dc.subjectCytotoxicen_US
dc.subjectLung canceren_US
dc.subjectAntimicrobialen_US
dc.titleSynthesis, cytotoxic and antimicrobial activities of novel cobalt and zinc complexes of benzimidazole derivativesen_US
dc.typeArticleen_US

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