Association of cardiac changes with serum adiponectin and resistin levels in obese and overweight children

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dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridKARAKURT, CEMŞIT/0000-0002-9246-8107
dc.authoridELKIRAN, OZLEM/0000-0002-6855-0346
dc.authoridAkinci, Aysehan/0000-0001-7267-9444
dc.authorwosidGüldür, Tayfun/AAA-7088-2021
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidKARAKURT, CEMŞIT/ABE-2330-2020
dc.authorwosidelkiran, ozlem/ABI-8212-2020
dc.authorwosidNalbantoğlu, Özlem/CAF-1682-2022
dc.authorwosidELKIRAN, OZLEM/AAG-2241-2020
dc.authorwosidAkinci, Aysehan/AAC-6847-2021
dc.contributor.authorAkinci, Aysehan
dc.contributor.authorKarakurt, Cemsit
dc.contributor.authorGurbuz, Sibel
dc.contributor.authorElkiran, Ozlem
dc.contributor.authorNalbantoglu, Ozlem
dc.contributor.authorKocak, Gulendam
dc.contributor.authorGuldur, Tayfun
dc.date.accessioned2024-08-04T20:37:27Z
dc.date.available2024-08-04T20:37:27Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives To investigate serum adiponectin and resistin levels in childhood obesity and their relationship with cardiac changes and insulin resistance. Methods Seventy-one obese and 24 overweight children and 40 healthy children and adolescents were selected for the study. Height and weight measurements, BMI values and BMI SD score values were obtained for each individual. After blood pressure measurement, left ventricular wall thickness, left ventricular mass, stroke volume, cardiac output, systolic and diastolic functions of the left ventricle were measured using an M-mode, two dimensional color-coded echocardiography device. Blood samples of the individuals were obtained for fasting blood sugar, total blood cholesterol, triglyceride, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, insulin, C-peptide, adiponectin and resistin values. Results Cholesterol and LDL values, homeostasis model assessment of insulin resistance, fasting insulin and fasting C-peptide values of the obese and overweight groups were higher (P<0.01). Adiponectin level (P<0.001) and resistin level (P<0.05) of the obese and overweight groups were lower than those of the control group (P<0.05). Echocardiographic evaluation showed diastolic dysfunction in addition to increased left ventricular wall thickness and left ventricle mass values in the obese and overweight children. We also detected a significant positive correlation among left ventricular mass, interventricular septum systolic diameter and resistin in obese children. Among the factors, resistin level was determined as an independent predictor of left ventricular mass in obese children. Conclusion In this study, even in asymptomatic obese and overweight children, cardiac structural and functional changes, such as increased left ventricular mass and diastolic dysfunction, were demonstrated. Although decreased adiponectin level was not related to cardiac changes, it was shown that decreased serum resistin levels in the obese cases lead to left ventricle hypertrophy.en_US
dc.identifier.doi10.2459/JCM.0b013e328351674e
dc.identifier.endpage234en_US
dc.identifier.issn1558-2027
dc.identifier.issn1558-2035
dc.identifier.issue3en_US
dc.identifier.pmid22441215en_US
dc.identifier.scopus2-s2.0-84874666908en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage228en_US
dc.identifier.urihttps://doi.org/10.2459/JCM.0b013e328351674e
dc.identifier.urihttps://hdl.handle.net/11616/95978
dc.identifier.volume14en_US
dc.identifier.wosWOS:000330352700008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Cardiovascular Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadiponectinen_US
dc.subjectcardiac changesen_US
dc.subjectchildhood obesityen_US
dc.subjectresistinen_US
dc.titleAssociation of cardiac changes with serum adiponectin and resistin levels in obese and overweight childrenen_US
dc.typeArticleen_US

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