Patient-Specific Lattice Cage Design for Cervical Spinal Fusion

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dc.contributor.authorBozyigit, Bulent
dc.contributor.authorOymak, Mehmet Akif
dc.contributor.authorBahce, Erkan
dc.contributor.authorSingh, Gurminder
dc.date.accessioned2026-04-04T13:30:45Z
dc.date.available2026-04-04T13:30:45Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractAIM: To propose a patient-specific interbody cage with graded stiffness distributions analogous to the Young's modulus of the cervical spinal bone interface in order to improve mechanical compatibility, promote physiological load sharing, and enhance osseointegration. MATERIAL and METHODS: A synthetic database of spinal bone Young modulus values was used, incorporating anatomical regions (cervical, thoracic, lumbar) and patient-specific factors (age, bone density, health status). A parametric generative design approach allowed dynamic modification of lattice unit cell geometry to achieve target stiffness values (200-3000 MPa) while preserving structural integrity. RESULTS: Finite element endplate analysis demonstrated a 30%-50% reduction in stress shielding compared with conventional solid or homogeneous mesh lattices. Additively manufactured prototypes showed tunable stiffness-porosity trade-offs, achieving yield strength >= 150 MPa while supporting osseointegration. CONCLUSION: This study demonstrates improved load distribution and reduced risk of cage collapse compared with cadaveric spine data. Integrating computational design, biomechanical compatibility, and additive manufacturing may facilitate the development of patient-specific spinal implants with superior mechanical and biological performance.
dc.identifier.doi10.5137/1019-5149.JTN.49659-25.3
dc.identifier.endpage81
dc.identifier.issn1019-5149
dc.identifier.issue1
dc.identifier.pmid41553224
dc.identifier.scopus2-s2.0-105029245244
dc.identifier.scopusqualityQ3
dc.identifier.startpage74
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.49659-25.3
dc.identifier.urihttps://hdl.handle.net/11616/108359
dc.identifier.volume36
dc.identifier.wosWOS:001683828400009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectInterbody cage implant
dc.subjectYoung's modulus
dc.subjectLattice generative design
dc.subjectAdditive manufacturing
dc.subjectFinite element analysis
dc.titlePatient-Specific Lattice Cage Design for Cervical Spinal Fusion
dc.typeArticle

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