The role of adrenomedullin in varicocele and impotence

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authorwosidSoylu, Ahmet/P-2015-2019
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.contributor.authorOzbek, E
dc.contributor.authorYurekli, M
dc.contributor.authorSoylu, A
dc.contributor.authorDavarci, M
dc.contributor.authorBalbay, MD
dc.date.accessioned2024-08-04T20:12:07Z
dc.date.available2024-08-04T20:12:07Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective To assess the levels of adrenomedullin (a vasodilatory peptide) in penile blood before and after injection with papaverine in impotent men, and in the internal spermatic vein in infertile patients with varicocele, comparing the results with levels in the brachial vein in the same patients. Patients and methods Intracavernosal levels of adrenomedullin were determined in 14 impotent men (with no vascular pathology, as assessed by colour Doppler ultrasonography) before and after papaverine-induced penile erection. The effect of needle puncture alone was assessed in eight control patients. The level of adrenomedullin was also measured in the internal spermatic vein and brachial vein in 14 infertile men with varicocele. Results The mean (SD) intracavernosal adrenomedullin levels in the 14 impotent men were significantly different between the flaccid and papaverine-induced erectile state, at 93.5 (33.0) and 135.8 (34.9) pmol/mL, respectively, (P < 0.05). Needle puncture alone had no effect on adrenomedullin levels. In men with varicocele, the adrenomedullin level of 139.0 (34.3) pmol/mL within the internal spermatic vein was significantly higher than that in the brachial vein, at 103.9 (37.6) pmol/mL (P < 0.05). Conclusion Injection with papaverine increases adrenomedullin release into penile blood; this release may be responsible for the increase in penile blood flow and penile erection. Higher levels of adrenomedullin within the internal spermatic vein of patients with varicocele may result from the retrograde flow of venous blood from the left adrenal gland and kidney. Further studies are needed to determine the role of adrenomedullin in male infertility and impotence.en_US
dc.identifier.doi10.1046/j.1464-410X.2000.00853.x
dc.identifier.endpage698en_US
dc.identifier.issn1464-4096
dc.identifier.issue6en_US
dc.identifier.pmid11069379en_US
dc.identifier.scopus2-s2.0-0033776288en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage694en_US
dc.identifier.urihttps://doi.org/10.1046/j.1464-410X.2000.00853.x
dc.identifier.urihttps://hdl.handle.net/11616/93219
dc.identifier.volume86en_US
dc.identifier.wosWOS:000089891600019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Science Ltden_US
dc.relation.ispartofBju Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectpapaverineen_US
dc.subjectimpotenceen_US
dc.subjectvaricoceleen_US
dc.subjectmale infertilityen_US
dc.titleThe role of adrenomedullin in varicocele and impotenceen_US
dc.typeArticleen_US

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