Investigation of the effect of gestational diabetes on fetal cardiac tissue in streptozotocin induced in rats1

Simple item page
dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidSimsek, Yavuz/AAH-9894-2021
dc.contributor.authorTurhan, Ugur
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorGul, Mehmet
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorOzyalin, Fatma
dc.contributor.authorParlakpinar, Hakan
dc.date.accessioned2024-08-04T20:44:30Z
dc.date.available2024-08-04T20:44:30Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To Investigate the cause of congenital anomalies resulted from gestational diabetes on fetal cardiac tissue in experimental animal study model. Methods: Totally 12 female WIstar albino rats were divided Into two groups, each consisting of 6 rats. Streptozotocln (60 mg/kg) was administered intraperltoneally to the study group by dissolving In citrate solution. The rats with a blood glucose level of 200 mg/dL and above were considered to be diabetic rats. Total antioxidant status (TAS), total oxidative stress (TOS) and oxidative stress Index (OSI) values were calculated In the cardiac tissues and maternal serum samples of the fetuses delivered by cesarean section after the mating process. The cardiac tissues were also subjected to hlstopathologlcal examination. Results: TOS and OSI values In fetal cardiac tissues of the diabetic rats were found to be significantly higher than that of the control group (p=0.026 and p=0.005). Histopathological examination revealed that the mitotic Index was lower and the cell organization was found to be damaged In the fetuses of the study group rats. Conclusion: Increased levels of free oxygen radicals considered to be due to hyperglycemia may cause congenital anomalies, especially during organogenesis period, by disrupting cell homeostasis and adversely affecting mitosis.en_US
dc.identifier.doi10.1590/s0102-865020180040000002
dc.identifier.endpage313en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue4en_US
dc.identifier.pmid29768533en_US
dc.identifier.scopus2-s2.0-85046994225en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage306en_US
dc.identifier.urihttps://doi.org/10.1590/s0102-865020180040000002
dc.identifier.urihttps://hdl.handle.net/11616/98289
dc.identifier.volume33en_US
dc.identifier.wosWOS:000432449900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectOxidative Stressen_US
dc.subjectHyperglycemiaen_US
dc.subjectDiabetesen_US
dc.subjectGestationalen_US
dc.subjectRatsen_US
dc.titleInvestigation of the effect of gestational diabetes on fetal cardiac tissue in streptozotocin induced in rats1en_US
dc.typeArticleen_US

Files

Collections

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu

We collect and process your personal information for the following purposes: Authentication, Preferences, Acknowledgement and Statistics.
To learn more, please read our privacy policy.

Customize