Evaluation of Effects of Topical Melatonin Application on Osseointegration of Dental Implant: An Experimental Study

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dc.authoridGul, Mehmet/0000-0002-5721-8778
dc.authoridÖzüpek, Muhammet Fatih/0000-0001-8922-3646
dc.authoridToy, Vesile Elif/0000-0001-5183-6295
dc.authoridÖZERCAN, ibrahim Hanifi/0000-0002-8781-8838
dc.authorwosidGul, Mehmet/AAU-1991-2020
dc.authorwosidÖzüpek, Muhammet Fatih/V-8169-2018
dc.authorwosidToy, Vesile Elif/ABH-9210-2020
dc.authorwosidDundar, Serkan/V-8159-2018
dc.authorwosidÖZERCAN, ibrahim Hanifi/W-7883-2018
dc.contributor.authorDundar, Serkan
dc.contributor.authorYaman, Ferhan
dc.contributor.authorSaybak, Arif
dc.contributor.authorOzupek, M. Fatih
dc.contributor.authorToy, Vesile Elif
dc.contributor.authorGul, Mehmet
dc.contributor.authorOzercan, I. Hanifi
dc.date.accessioned2024-08-04T20:42:43Z
dc.date.available2024-08-04T20:42:43Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the present study was to evaluate the effect of local melatonin application during surgery on bone implant connection (BIC) in rabbit tibiae. Six 0.8- to 1-year-old male New Zealand rabbits were divided into 3 groups: (1) a control group (CG) in which rabbits were not treated with additive materials and only implant integration was executed; (2) a melatonin dose 1 (MLT D-1) group in which rabbits were treated with 1.2 mg of melatonin locally before implant placement into the rabbits' tibiae; and (3) a melatonin dose 2 (MLT D-2) group in which rabbits were treated with 3 mg melatonin locally before implant placement into the rabbits' tibiae. Four weeks after the procedure, the rabbits were euthanized; their tibiae were dissected from muscles and soft tissues, fixed with formaldehyde, and later embedded in methacrylate. Histologic and histomorphometric analyses were then performed under light microscopy. Following this, BIC was detected histomorphometrically, and P<.05 was considered statistically significant. Results showed that the highest BIC percentage was detected in MLT D-2, with a mean value of 39.46% +/- 0.78, as compared with a mean value of 33.89% +/- 0.92 in group MLT D-1 and 27.42% +/- 0.89 in CG. Similarly, the mean BIC percentage of the MLT D-2 group was the highest among the three, with the mean BIC percentage of the MLT D-1 still registering as higher than CG. Within the limitations of this rabbit study, it appears that local melatonin application during implant surgery may improve BIC.en_US
dc.identifier.doi10.1563/aaid-joi-D-16-00048
dc.identifier.endpage389en_US
dc.identifier.issn0160-6972
dc.identifier.issn1548-1336
dc.identifier.issue5en_US
dc.identifier.pmid27327091en_US
dc.identifier.scopus2-s2.0-84992184213en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage386en_US
dc.identifier.urihttps://doi.org/10.1563/aaid-joi-D-16-00048
dc.identifier.urihttps://hdl.handle.net/11616/97545
dc.identifier.volume42en_US
dc.identifier.wosWOS:000385087800002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAllen Press Incen_US
dc.relation.ispartofJournal of Oral Implantologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbone implant connectionen_US
dc.subjectimplanten_US
dc.subjectlocal melatoninen_US
dc.subjectrabbiten_US
dc.subjectboneen_US
dc.titleEvaluation of Effects of Topical Melatonin Application on Osseointegration of Dental Implant: An Experimental Studyen_US
dc.typeArticleen_US

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