Lung function outcomes of cystic fibrosis patients after early-life pulmonary exacerbations: National registry analysis

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dc.contributor.authorOzkan Tabakci, Sati
dc.contributor.authorUytun, Salih
dc.contributor.authorEryilmaz Polat, Sanem
dc.contributor.authorCinel, Guzin
dc.contributor.authorYalcin, Ebru
dc.contributor.authorKiper, Nural
dc.contributor.authorAkgul Erdal, Meltem
dc.date.accessioned2026-04-04T13:33:19Z
dc.date.available2026-04-04T13:33:19Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground Pulmonary exacerbations (PEs) are associated with a subsequent decline in lung function. We aim to evaluate lung function in cystic fibrosis (CF) patients with frequent PEs in their first 2 years of age using spirometry at age 6. Methods This retrospective cohort study included CF patients who were 6 years old from the CF registry of Turkey in 2019. According to the number of PEs, patients were classified: those who had two or fewer PEs in the first 2 years of age were defined as Group 1 and those who had more than two PEs were defined as Group 2. The patients' demographics and clinical characteristics were compared between Group 1 and Group 2. Results The study included 88 patients who had data on PE from their first 2 years and completed their sixth year by 2019. Fifty-nine patients were included in Group 1 and 29 in Group 2. The mean percent-predictive FEV1 (ppFEV1), percent-predictive FVC (ppFVC) values, and the mean age at first PE were lower in Group 2 than in Group 1 (p = 0.019, p = 0.017, p < 0.001). The patients with chronic Pseudomonas aeruginosa (PA) colonization had lower mean ppFEV1 and ppFVC values than those without (p = 0.001, p = 0.001). Patients with PA in respiratory-sample culture during their first PE had lower ppFEV1 and ppFVC values than those with SA (p = 0.046; 0.018). Conclusions This study showed that more frequent PEs in the first 2 years of age and chronic PA colonization were associated with poorer FEV1, FVC, and BMI values in CF patients.
dc.identifier.doi10.1111/ped.70345
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue1
dc.identifier.orcid0000-0003-2309-7952
dc.identifier.pmid41660807
dc.identifier.scopus2-s2.0-105029592382
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1111/ped.70345
dc.identifier.urihttps://hdl.handle.net/11616/109078
dc.identifier.volume68
dc.identifier.wosWOS:001685963800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofPediatrics International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectchronic colonization
dc.subjectcystic fibrosis
dc.subjectpulmonary exacerbation
dc.subjectrespiratory function
dc.titleLung function outcomes of cystic fibrosis patients after early-life pulmonary exacerbations: National registry analysis
dc.typeArticle

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