Synthesis and antitumor activity of new silver(I)-N-heterocyclic carbene complexes

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dc.authoridŞAHİN-BÖLÜKBAŞI, Serap/0000-0003-1057-2558;
dc.authorwosidŞAHİN-BÖLÜKBAŞI, Serap/ABJ-7836-2022
dc.authorwosidŞAHİN, Neslihan/F-6402-2019
dc.contributor.authorSahin, Neslihan
dc.contributor.authorSahin-Bolukbasi, Serap
dc.contributor.authorMarsan, Halis
dc.date.accessioned2024-08-04T20:47:02Z
dc.date.available2024-08-04T20:47:02Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, two novel benzimidazole-based N-heterocyclic carbene ligands (1a-b) and their silver(I) complexes (2a-b) were synthesized. All new compounds were characterized by FT-IR, LC-MS, H-1 NMR, and C-13 NMR spectroscopies. The in vitro antitumor activities of NHC ligands (1a-b) and their silver(I) complexes (2a-b) against DU-145 human prostate cancer cells, MDA-MB-231 and MCF-7 human breast cancer cells and L-929 (normal cells adipose from mouse) were also determined using MTT analysis for 24 h, 48 h, and 72 h. The results showed that while NHC ligands did not have in vitro antitumor activity on MCF-7, MDA-MB-231 and DU-145 cells, Ag(I)-NHC complexes have in vitro antitumor activities. The in vitro antitumor activity of 2a was found to be lower than that of 2b. Ag(I)-NHC complexes were observed to have higher IC50 values for non-cancerous cell lines than cancer cells.en_US
dc.identifier.doi10.1080/00958972.2019.1697808
dc.identifier.endpage3613en_US
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue22-24en_US
dc.identifier.scopus2-s2.0-85076375951en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3602en_US
dc.identifier.urihttps://doi.org/10.1080/00958972.2019.1697808
dc.identifier.urihttps://hdl.handle.net/11616/99098
dc.identifier.volume72en_US
dc.identifier.wosWOS:000501099100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Coordination Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbineen_US
dc.subjectbenzimidazole-2-ylideneen_US
dc.subjectsilveren_US
dc.subjectanticancer activityen_US
dc.titleSynthesis and antitumor activity of new silver(I)-N-heterocyclic carbene complexesen_US
dc.typeArticleen_US

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