Prognostic significance of tumor grade in early-stage endometrioid endometrial cancer
| dc.contributor.author | Akar, Serra | |
| dc.contributor.author | Harmankaya, Ismail | |
| dc.contributor.author | Celik, Cetin | |
| dc.date.accessioned | 2022-03-07T16:49:40Z | |
| dc.date.available | 2022-03-07T16:49:40Z | |
| dc.date.issued | 2019 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Aim: Although tumor grade has no impact on endometrial cancer stage, it carries prognostic and therapeutic importance. Surgical management and adjuvant treatment following surgery in certain patients depends on a number of factors including tumor grade. Although grade 3 tumors are included in the high-intermediate risk group, there are data demonstrating that there is a slight difference in survival between patients with grade 1 and 2 tumors in early-stage disease. In this study, we aimed to investigate the association of grade with clinicopathological characteristics, recurrence-free and disease-specific survival in patients treated at our clinic and diagnosed with endometrioid endometrial cancer. Material and Methods: 279 patients with early FIGO Stage endometrioid endometrial cancer treated between 2009-2018 in a University hospital were included in the study. The associations between tumor grade with stage, lymphovascular space invasion (LVSI), myometrial invasion, tumor size, and survival were analyzed.Results: LVSI, ≥50% myometrial invasion, advanced stage and > 2 cm tumor size were significantly higher in grade 3 tumors compared to patients with grade 1 tumors. Recurrence-free and disease-specific survival were significantly lower in patients with grade 2 and 3 tumors compared to patients with grade 1 tumors. In multivariate analysis of RFS and DSS, tumor grade, LVSI and stage were independent prognostic factors.Conclusion: According to this study, grade 2 tumors may not differ significantly from grade 3 tumors in terms of survival. Therefore, due to the potential adverse prognosis associated with grade 2 and 3 tumors, vigilance for recurrence is warranted. | en_US |
| dc.identifier.citation | Akar, S., Harmankaya, I., & Celik, C. (2021). Prognostic significance of tumor grade in early-stage endometrioid endometrial cancer . Annals of Medical Research, | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/54563 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Prognostic significance of tumor grade in early-stage endometrioid endometrial cancer | en_US |
| dc.type | Article | en_US |
