Economic growth leads to increase of obesity and associated hepatocellular carcinoma in developing countries

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dc.authoridKucukoglu, Ozlem/0000-0002-4217-9075
dc.authoridSEYDEL, GONUL SEYDA/0000-0001-9317-0719
dc.authorwosidCanbay, Ali/AAL-9620-2020
dc.authorwosidKucukoglu, Ozlem/J-4713-2019
dc.authorwosidSowa, Jan-Peter/AAQ-6318-2020
dc.authorwosidSEYDEL, GONUL SEYDA/AAD-6602-2021
dc.contributor.authorSeydel, G. Seyda
dc.contributor.authorKucukoglu, Ozlem
dc.contributor.authorAltinbas, Akif
dc.contributor.authorDemir, O. Oguz
dc.contributor.authorYilmaz, Sezai
dc.contributor.authorAkkiz, Hikmet
dc.contributor.authorOtan, Emrah
dc.date.accessioned2024-08-04T20:42:36Z
dc.date.available2024-08-04T20:42:36Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHepatocellular carcinoma (HCC) is the most common type of primary liver cancer and the third leading cause of cancer related death worldwide. In recent years, the prevalence of HCC has increased in both developing and developed countries. Most HCC cases develop in the presence of advanced chronic liver disease related to viral hepatitis. In particular hepatitis B virus and hepatitis C virus infections are considered as major HCC risk factors worldwide. However, current studies provide strong evidence for increasing numbers of HCC in nonalcoholic fatty liver disease (NAFLD). NAFLD represents the hepatic manifestation of metabolic syndrome which is based on obesity and insulin resistance. Epidemiologic data clearly demonstrates that NAFLD and obesity-related disorders are significant risk factors for tumor development in general and HCC in particular. As a consequence of life style changes towards higher calorie intake and less exercise, obesity and metabolic syndrome are spreading all over the world. Due to this increase in obesity and metabolic syndrome NAFLD-related HCC will become a major health care problem in the future. In conclusion, better understanding of the impact of NAFLD and obesity in the development of HCC will improve our treatment strategies of HCC and allow preventive measures.en_US
dc.description.sponsorshipWilhelm Laupitz Foundation; TUBITAK-2219 Post-doc research scholarship programen_US
dc.description.sponsorshipSupported by the Wilhelm Laupitz Foundation (A.C.) and by the TUBITAK-2219 Post-doc research scholarship program (A.A.).en_US
dc.identifier.doi10.5604/16652681.1212316
dc.identifier.endpage672en_US
dc.identifier.issn1665-2681
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84982952592en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage662en_US
dc.identifier.urihttps://doi.org/10.5604/16652681.1212316
dc.identifier.urihttps://hdl.handle.net/11616/97475
dc.identifier.volume15en_US
dc.identifier.wosWOS:000397061200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Espanaen_US
dc.relation.ispartofAnnals of Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNonalcoholic fatty liver diseaseen_US
dc.subjectMetabolic syndromeen_US
dc.subjectEpidemiologyen_US
dc.titleEconomic growth leads to increase of obesity and associated hepatocellular carcinoma in developing countriesen_US
dc.typeReview Articleen_US

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