Effects of dexmedetomidine and midazolam on motor coordination and analgesia: A comparative analysis

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dc.authorscopusid47460989500
dc.authorscopusid6602664864
dc.authorscopusid55178121700
dc.authorscopusid7005217039
dc.authorscopusid56244596600
dc.authorscopusid55324126600
dc.authorscopusid11738942300
dc.contributor.authorAydogan M.S.
dc.contributor.authorParlakpinar H.
dc.contributor.authorAli Erdogan M.
dc.contributor.authorYucel A.
dc.contributor.authorUcar M.
dc.contributor.authorSa?ir M.
dc.contributor.authorColak C.
dc.date.accessioned2024-08-04T19:59:06Z
dc.date.available2024-08-04T19:59:06Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: We compared the effects of 2 sedative drugs, dexmedetomidine and midazolam, on motor performance and analgesic efficacy in a rat model. Materials and methods: Rats were randomly divided into the following 4 groups on the basis of the treatment received. The first group received 83 ?g/kg/min midazolam; the second, 1 ?g/kg/min dexmedetomidine; the third, 83 ?g/kg/min morphine; and the fourth was a control group. The rats were measured motor coordination and pain reflexes by using rotarod, accelerod, hot plate, and tail flick tests. Results: At all the tested speeds, the midazolam-injected rats remained on the rotarod longer than did the dexmedetomidine-injected rats. Furthermore, in the 10-minute accelerod test, the midazolam-injected rats remained for a longer duration than did the dexmedetomidine-injected rats. The latency time for the hot plate test was significantly higher at 10 minutes and 20 minutes in the dexmedetomidine group than in the midazolam group. Further, the latency time at 10 minutes for the tail flick test was greater in the dexmedetomidine group than in the midazolam group. Conclusions: In this rat model, midazolam results in faster recovery of motor coordination performance when compared with dexmedetomidine. © 2013 The Authors.en_US
dc.identifier.doi10.1016/j.curtheres.2013.05.003
dc.identifier.endpage26en_US
dc.identifier.issn0011-393X
dc.identifier.scopus2-s2.0-84890243732en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage22en_US
dc.identifier.urihttps://doi.org/10.1016/j.curtheres.2013.05.003
dc.identifier.urihttps://hdl.handle.net/11616/90385
dc.identifier.volume75en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofCurrent Therapeutic Research - Clinical and Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcceleroden_US
dc.subjectDexmedetomidineen_US
dc.subjectHot plateen_US
dc.subjectMidazolamen_US
dc.subjectMotor impairmenten_US
dc.subjectRotaroden_US
dc.subjectTail flicken_US
dc.titleEffects of dexmedetomidine and midazolam on motor coordination and analgesia: A comparative analysisen_US
dc.typeArticleen_US

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