Deneysel Toksoplasma gondii infeksiyonlarında serum çinko düzeyleri ve çinko takviyesinin hücresel bağışıklıktaki etkisi
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Dosyalar
Tarih
1995
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi Tıp Fakültesi Dergisi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
liıı araştırmada, deneysel olarak oluşturulmuş Toksoplazma gondii infeksiyonunda, serum çinko düzeylerinin belirlenmesinin yanısıra, çinko takviyesinin hücresel bağışıklık üzerine olan etki derecesinin ortaya konulması amaçlandı. Çalışmada 50 adet Wistar-A Ibino erkek rafların 20'si çinko takviyeli diyetle beslenen infeksiyonlu deney grubunu (İD), 20'si normal diyetle beslenen infeksiyonlu kontrol grubunu (İK) ve 10 tanesi normal diyetle beslenen infeksiy onsuz kontrol grubunu (K) oluşturdu. Grupların serum çinko düzeyleri ve immünolojik parametreleri değerlendirildi. Total ve T8 lenfositler İD ve İK gruplarında yüksek olarak gözlenirken, T4 lenfositler K grubunda yüksek bulundu (P < 0.001). Serum çinko seviyeleri arasında anlamlı farklılık tesbit edilmedi. Her iki kontrol grubunda T4-T8 lenfositleri arasında, İD grubunda T8- lenfositleriyle serum çinko seviyeleri arasında korelasyon görülürken, diğer parametreler anlamsız bulundu. Çinko takviyesinin T.gondii infeksiyonunda T8-lenfosit yapımını artırarak hücresel bağışıklık sistemini uyardığı, dolayısıyla parazitik infeksiyonlarda yürütülen tedavi yanında çinko takviyesinin yararlı olabileceği sonucuna varıldı.
bifly Wistar-Albino male rats were divided into three groups each containing 10, 20 and 20 rats to represent the control (C). infected with zinc supplemented diet (ID) and infected without zinc supplemented diet (IK) groups, respectively, in order to determine the serum zinc levels and the effect of zinc supplement on the cellular immunity in experimentally induced T.gondii infection. Serum zinc levels and some immunologic parameters of rats were determined. Total and T8 lymphocytes were high in ID and IK groups while T4 lymphocyte was high in K group (P < 0.001). No difference was observed between the serum zinc levels of all groups. In the correlation coefficient calculations a positive relation was found between T4 and T8 lymphocytes in both K and IK groups, though there was not any relation in the other parameters and, also a positive relation was observed between the T8 lymphocytes and serum zinc levels in the supplemented infected group. It was observed in this study that zinc supplementation stimulates the immune system by increasing the T8 lymphocyte production and it may be concluded that zinc supplementation might be useful besides the therapeutic treatments for parasitic infections.
bifly Wistar-Albino male rats were divided into three groups each containing 10, 20 and 20 rats to represent the control (C). infected with zinc supplemented diet (ID) and infected without zinc supplemented diet (IK) groups, respectively, in order to determine the serum zinc levels and the effect of zinc supplement on the cellular immunity in experimentally induced T.gondii infection. Serum zinc levels and some immunologic parameters of rats were determined. Total and T8 lymphocytes were high in ID and IK groups while T4 lymphocyte was high in K group (P < 0.001). No difference was observed between the serum zinc levels of all groups. In the correlation coefficient calculations a positive relation was found between T4 and T8 lymphocytes in both K and IK groups, though there was not any relation in the other parameters and, also a positive relation was observed between the T8 lymphocytes and serum zinc levels in the supplemented infected group. It was observed in this study that zinc supplementation stimulates the immune system by increasing the T8 lymphocyte production and it may be concluded that zinc supplementation might be useful besides the therapeutic treatments for parasitic infections.
Açıklama
Journal of Turgut Özal Medical Center 2(2): 130-134,1995]
Anahtar Kelimeler
T.gondii, Çinko, Hücresel bağışıklık, Toxoplasma gondii, Zinc, Cellular immunity
Kaynak
Turgut Özal Tıp Merkezi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
2
Sayı
2
Künye
K.Baltacı, Abdülkerim.,Ergene, N., Ateş, A.,Ş.Bediz, Cem.,Özmedivenli, R.,Duman, S.,
(1995). Deneysel Toksoplasma gondii infeksiyonlarında serum çinko düzeyleri ve çinko takviyesinin hücresel bağışıklıktaki etkisi.130-134 ss.
