Treatment results of chronic hepatitis B in children: a retrospective study

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dc.contributor.authorSelimoglu, Mukadder Ayse
dc.contributor.authorErtekin, Vildan
dc.contributor.authorKarabiber, Hamza
dc.contributor.authorTurgut, Ahmet
dc.contributor.authorGursan, Nesrin
dc.date.accessioned2024-08-04T20:32:40Z
dc.date.available2024-08-04T20:32:40Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSelimoglu MA, Ertekin V, Karabiber H, Turgut A, Gursan N. Treatment results of chronic hepatitis B in children: a retrospective study. Turk J Pediatr 2010; 52: 360-366. In this retrospective study, we aimed to share our experience with different treatment modalities for chronic hepatitis B in a series of children. The study included 126 children (mean: 9.5+/-3.8 years). Normalization of alanine aminotransferase (ALT), loss of hepatitis B virus (HBV)-DNA and hepatitis B e antigen (HBeAg), and development of antibody to HBeAg (anti-HBe) altogether at the end of the treatment was considered as end of therapy response (ETR). Seroconversion ongoing one year after the cessation of therapy was considered as sustained response. Of the total children, 90 (71.4%) were treated, whereas the remaining were just followed-up. High-dose interferon (IFN)-alpha (10 MU/m(2)) alone, standard-dose IFN-alpha (6 MU/m(2)) plus lamivudine (4 mg/kg/d), high-dose IFN-alpha plus lamivudine, or lamivudine alone was used, IFN-alpha thrice weekly for six months, and lamivudine daily for one year. Of children who had completed their treatment, 34 (37.8%) achieved ETR. Sustained response rate was 36.7%. Response rates were different in the different treatment groups (p: 0.01). The highest response rate was observed in those who received standard-dose IFN-alpha plus lamivudine treatment (61.5%). Of children without treatment, one (2.8%) had anti-HBe seroconversion. Standard-dose IFN-alpha plus lamivudine treatment was found superior to the other treatment modalities. Predictors of ETR were similar to those found in previous studies.en_US
dc.identifier.endpage366en_US
dc.identifier.issn0041-4301
dc.identifier.issue4en_US
dc.identifier.pmid21043380en_US
dc.identifier.scopus2-s2.0-78649704466en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage360en_US
dc.identifier.urihttps://hdl.handle.net/11616/95199
dc.identifier.volume52en_US
dc.identifier.wosWOS:000283470400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish J Pediatricsen_US
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchronic hepatitis Ben_US
dc.subjecttreatmenten_US
dc.subjectchildrenen_US
dc.titleTreatment results of chronic hepatitis B in children: a retrospective studyen_US
dc.typeArticleen_US

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