Amino asit içeren kinolinon türevlerinin sentezi ve özelliklerinin incelenmesi
Yükleniyor...
Dosyalar
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Kinolinler piridin sınıfına dahil olan, piridin halkasına bitişik benzen türevleri olarak tanımlanabilen ve taşıdıkları sübstitüyentlere göre çeşitli farmakolojik özellikler gösteren bileşiklerdir. Doğal ve sentetik kinolinlerin antifungal, antitümör, HIV replikasyon inhibitörü ve antibakteriyal özelliklere sahip oldukları bilinmektedir. Ayrıca sıtma tedavisinde kullanılan klorokin, amodiakin, dibukain hidroklorür ve önemli bir boyar madde olan siyoninde yapay kinolin bileşikleridir. Amino asitler ve peptit serileri geniş spektrumda biyolojik aktiviteye sahip bileşiklerdir. Amino asit ve peptitlerin muhtemel biyolojik aktif heterosiklik yapılarla birleştirilmesinde Katritzky grubu tarafından geliştirilen N-acilbenzotriazol metodu oldukça etkin bir sentez metodudur. Ayrıca sentezlenmesi amaçlanan bileşiklerin, amino asit/peptit içeriğinden dolayı yüksek bir biyouyumluluğa sahip olması dolaysıyla iyi bir biyolojik aktivite göstermeleri de beklenmektedir. Bu Yüksek Lisans tezi kapsamında kinolinler ile N-acilbenzotriazollerin etkileştirilmesi ile 19 adet yeni amino asit türevi içeren kinolin türevleri sentezlenmiş ve yapıları, 1H-NMR, 13C-NMR, MS, FT-R spektroskopisi ve element analizi teknikleri ile aydınlatılmıştır. ANAHTAR KELİMELER: Amino asit, dipeptit, kinolin, N-(α-acilbenzotriazol)
Quinolines exhibit a variety of pharmacological properties according to the substituents they contain, which can be identified as benzene derivatives adjacent to the pyridine ring, which belong to the pyridine class. Natural and synthetic quinolines are known to have antifungal, antitumor, HIV replication inhibitor and antibacterial properties. Furthermore, chloroquine, amodiakine, dibucaine hydrochloride and artificial quinoline, an important dye, are used in the treatment of diseases. Amino acids and peptide sequences are compounds with a broad spectrum of biological activity. Amio acid and peptide conjugates are compounds of great importance in understanding biological functions. The N-acyl benzotriazole method developed by the Katritzky group is a highly effective synthesis method for the coupling of amino acids and peptides with possible biologically active heterocyclic structures. It is also expected that the compounds intended to be synthesized exhibit good biological activity due to their high biocompatibility due to their amino acid / peptide content. In this Master's thesis, 19 new amino acid or dipeptide-quinoline derivatives were synthesized sucessfully and their structures were elucidated by 1H-NMR, 13C-NMR, MS, FT-R spectroscopy and element analysis techniques. KEYWORDS: Amino acid, dipeptide, quinoline, N- (α-acilbenzotriazoles)
Quinolines exhibit a variety of pharmacological properties according to the substituents they contain, which can be identified as benzene derivatives adjacent to the pyridine ring, which belong to the pyridine class. Natural and synthetic quinolines are known to have antifungal, antitumor, HIV replication inhibitor and antibacterial properties. Furthermore, chloroquine, amodiakine, dibucaine hydrochloride and artificial quinoline, an important dye, are used in the treatment of diseases. Amino acids and peptide sequences are compounds with a broad spectrum of biological activity. Amio acid and peptide conjugates are compounds of great importance in understanding biological functions. The N-acyl benzotriazole method developed by the Katritzky group is a highly effective synthesis method for the coupling of amino acids and peptides with possible biologically active heterocyclic structures. It is also expected that the compounds intended to be synthesized exhibit good biological activity due to their high biocompatibility due to their amino acid / peptide content. In this Master's thesis, 19 new amino acid or dipeptide-quinoline derivatives were synthesized sucessfully and their structures were elucidated by 1H-NMR, 13C-NMR, MS, FT-R spectroscopy and element analysis techniques. KEYWORDS: Amino acid, dipeptide, quinoline, N- (α-acilbenzotriazoles)
Açıklama
Anahtar Kelimeler
Chemistry, Kimya
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Gönül, Y. (2020). Amino asit içeren kinolinon türevlerinin sentezi ve özelliklerinin incelenmesi. Yayınlanmış Yüksek Lisans Tezi, İnönü Üniversitesi.
