Kisspeptin antagonist prevents RF9-induced reproductive changes in female rats

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dc.authoridSahin, Zafer/0000-0001-7982-7155
dc.authoridOzcan, Mete/0000-0002-5551-4880;
dc.authorwosidSahin, Zafer/ABD-5367-2020
dc.authorwosidCanpolat, Sinan/V-8968-2018
dc.authorwosidOzcan, Mete/V-8758-2018
dc.authorwosidÖzgöçer, Tuba/AAA-1751-2021
dc.authorwosidKelestimur, Haluk/V-9392-2018
dc.contributor.authorSahin, Zafer
dc.contributor.authorCanpolat, Sinan
dc.contributor.authorOzcan, Mete
dc.contributor.authorOzgocer, Tuba
dc.contributor.authorKelestimur, Haluk
dc.date.accessioned2024-08-04T20:40:12Z
dc.date.available2024-08-04T20:40:12Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the modulatory effects of peptide 234 (p234) (an antagonist of GPR54 receptors) on kisspeptin and RF9 (an RFamide-related peptide antagonist)-induced changes in reproductive functions and energy balance in female rats. Female Sprague-Dawley rats were weaned on postnatal day (pnd) 21. The animals were intracerebroventricularly cannulated under general anesthesia on pnd 23. Groups of female rats were injected with kisspeptin, RF9, p234, kisspeptin plus p234, or RF9 plus p234, daily. The experiments were ended on the day of first diestrus following pnd 60. Kisspeptin or RF9 alone advanced vaginal opening (VO), which was delayed by administration of kisspeptin antagonist alone. In the rats given kisspeptin plus p234 or RF9 plus p234, VO was not different from control rats. Kisspeptin and RF9 elicited significant elevations in circulating LH levels. Coadministrations of kisspeptin or RF9 with p234 decreased LH levels significantly. The use of p234 alone did not cause any significant change in LH secretion. Kisspeptin decreased both food intake and body weight while RF9 decreased only food intake without affecting body weight. The effects of kisspeptin on energy balance were also reversed by central administration of p234. In conclusion, kisspeptin antagonist, p234, modulates the effects of kisspeptin on reproductive functions and energy balance, whereas RF9 seems to exert only its effects on reproductive functions by means of GPR54 signaling in female rats.en_US
dc.description.sponsorship[TUBITAK-113S193]en_US
dc.description.sponsorshipThis work was supported by TUBITAK-113S193.en_US
dc.identifier.doi10.1530/REP-14-0683
dc.identifier.endpage473en_US
dc.identifier.issn1470-1626
dc.identifier.issue5en_US
dc.identifier.pmid25713426en_US
dc.identifier.scopus2-s2.0-84929179402en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage465en_US
dc.identifier.urihttps://doi.org/10.1530/REP-14-0683
dc.identifier.urihttps://hdl.handle.net/11616/96782
dc.identifier.volume149en_US
dc.identifier.wosWOS:000353660700011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBioscientifica Ltden_US
dc.relation.ispartofReproductionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProtein-Coupled Receptoren_US
dc.subjectAmide-Related Peptidesen_US
dc.subjectHormone Neuronsen_US
dc.subjectNeuropeptide-Yen_US
dc.subjectFood-Intakeen_US
dc.subjectAdult Maleen_US
dc.subjectGonadotropinen_US
dc.subjectExpressionen_US
dc.subjectSecretionen_US
dc.subjectSystemen_US
dc.titleKisspeptin antagonist prevents RF9-induced reproductive changes in female ratsen_US
dc.typeArticleen_US

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