The role of prokineticins in recurrent implantation failure

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dc.authoridSEMERCİ SEVİMLİ, Tuğba/0000-0003-4856-2304
dc.authoridKaraer, Abdullah/0000-0002-2010-6211
dc.authoridEKER SARIBOYACI, AYLA/0000-0003-4536-9859
dc.authoridKarabulut Dogan, Umran/0000-0002-1935-3696
dc.authorwosidTuncay, Görkem/ABI-6418-2020
dc.authorwosidSEMERCİ SEVİMLİ, Tuğba/AAA-5601-2021
dc.authorwosidKaraer, Abdullah/ABI-4667-2020
dc.authorwosidEKER SARIBOYACI, AYLA/AAG-5014-2019
dc.contributor.authorKaraer, Abdullah
dc.contributor.authorTuncay, Gorkem
dc.contributor.authorUysal, Onur
dc.contributor.authorSevimli, Tugba Semerci
dc.contributor.authorSahin, Nurhan
dc.contributor.authorKarabulut, Umran
dc.contributor.authorSariboyaci, Ayla Eker
dc.date.accessioned2024-08-04T20:47:26Z
dc.date.available2024-08-04T20:47:26Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the expression patterns of prokineticins (PROK) and prokineticin receptors (PROKR) in the endometrium of women with recurrent implantation failure (RIF). Fifteen (15) women with RIF and 15 fertile controls were enrolled in this study. Endometrial samples were taken from study participants with an endometrial biopsy cannula during the implantation window. Real time polymerase chain reaction and immunohistochemistry were used to determine PROK/PROKR mRNA expression and protein localization, respectively. PROK1 mRNA levels were 6.09 times higher compared to endometrial samples obtained from women with RIF than in samples obtained from fertile controls, whereas PROKR1 mRNA levels were 2.46 times lower in endometrial samples obtained from women with RIF than in samples from fertile controls. In addition, decreased PROKR1 was supported by immunohistochemistry analysis at protein level. There was no statistically significant difference between women with RIF and fertile controls regarding PROK2 and PROKR2 levels. Altered expression of the PROK1/PROKR1 system could be one of the numerous abnormalities in the endometrium of women with RIF. (C) 2020 Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipScientific Research Projects Unit of Inonu University [2014/39]en_US
dc.description.sponsorshipThe study was supported by Scientific Research Projects Unit of Inonu University [under grant number 2014/39].en_US
dc.identifier.doi10.1016/j.jogoh.2020.101835
dc.identifier.issn2468-7847
dc.identifier.issn1773-0430
dc.identifier.issue9en_US
dc.identifier.pmid32585394en_US
dc.identifier.scopus2-s2.0-85087125320en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jogoh.2020.101835
dc.identifier.urihttps://hdl.handle.net/11616/99373
dc.identifier.volume49en_US
dc.identifier.wosWOS:000583846900014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Masson, Corp Offen_US
dc.relation.ispartofJournal of Gynecology Obstetrics and Human Reproductionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometriumen_US
dc.subjectIn vitro fertilizationen_US
dc.subjectProkineticinen_US
dc.subjectRecurrent implantation failureen_US
dc.titleThe role of prokineticins in recurrent implantation failureen_US
dc.typeArticleen_US

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