Investigation into the protective effects of Naringenin in phthalates-induced reproductive damage

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dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorTaslidere, A.
dc.contributor.authorTurkmen, N. B.
dc.contributor.authorCiftci, O.
dc.contributor.authorAydin, M.
dc.date.accessioned2024-08-04T20:52:00Z
dc.date.available2024-08-04T20:52:00Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: Di-n-butyl phthalate (DBP) is a ubiquitous environmental pollutant, extensively used as a plasticizer in many products, including plastics. cosmetics. and medical devices. Naringenin (NAR) is a flavonoid belonging to the flavanones subclass. It is widely distributed in several citrus fruits, bergamot, tomatoes, and other fruits. It is also found in its glycoside form (mainly naringin). Several biological activities have been ascribed to this phytochemical: antioxidant, antitumor, antiviral, antibacterial, anti-inflammatory, antiadipogenic, and ca rdioprotective effects. This study hypothesized that phthalates' possible reproductive damage mechanism is oxidative attack, and naringenin could have a protective effect against radical forms in the body through its antioxidant properties. MATERIALS AND METHODS: Thirty-two male rats were used in our study (n=8 each). Rats were randomly divided into four groups: Control, DBP, DBP +NAR and NAR. Phthalate (DBP) and NAR were administered through gastric oral gavage (phthalate group 500 mg/kg/day DBP: NAR group 50 mg/kg/day NAR). At the end of four weeks. testis tissue samples were taken under anesthesia. Testis tissue and blood samples were collected from the four groups in this study. Histological, biochemical and spermatological analyses were conducted. RESULTS: Tissue samples from the control and NAR groups showed normal histological appearance on light microscopy. The DBP group exhibited deterioration in seminiferous tubules, vascular congestion in capsule, vascular congestion between the seminiferous tubules, edema in the intestinal area and vacuolization. arrested spermatocytes in different stages of division; sloughing of cells into the seminiferous tubular lumen was observed. it was also observed that NAR treatment significantly inhibited and prevented the histopathological damage caused by DBP. Tissue TBARS, antioxidant parameters, sperm motility, sperm density and abnormal spermatozoon ratios were determined. As a result, it was shown that DBP caused oxidative damage by increas- ing TBARS levels and decreasing antioxidant parameters. increased abnormal sperm rate and decreased sperm motility. and concentration and histopathological damage, so the antioxidant activity of naringenin inhibited this damage. CONCLUSIONS: DBP had toxic effects in rat testis tissue: NAR treatment ameliorated these effects. Further studies are warranted to confirm our findings.en_US
dc.description.sponsorshipScientific Research Projects Unit of Inonu Universityen_US
dc.description.sponsorshipWe would like to thank the Scientific Research Projects Unit of Inonu University for their support.en_US
dc.identifier.endpage3429en_US
dc.identifier.issn1128-3602
dc.identifier.issue10en_US
dc.identifier.pmid35647821en_US
dc.identifier.scopus2-s2.0-85131223026en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3419en_US
dc.identifier.urihttps://hdl.handle.net/11616/100690
dc.identifier.volume26en_US
dc.identifier.wosWOS:000809239500004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDi-n-butyl phthalateen_US
dc.subjectNaringeninen_US
dc.subjectOxidative stressen_US
dc.subjectSpermiotoxicityen_US
dc.subjectTesticular damageen_US
dc.titleInvestigation into the protective effects of Naringenin in phthalates-induced reproductive damageen_US
dc.typeArticleen_US

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