Insulin-like growth factor binding proteins (IGFBPs) in serum and urine and IGFBP-2 protease activity in patients with insulin-dependent diabetes mellitus

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dc.contributor.authorAkinci, A
dc.contributor.authorCopeland, KC
dc.contributor.authorGarmong, A
dc.contributor.authorClemmons, DR
dc.date.accessioned2024-08-04T20:12:09Z
dc.date.available2024-08-04T20:12:09Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDiabetes mellitus and glucose dysregulation have significant effects on the circulating level of insulin-like growth factor-I (IGF-I) and IGF binding proteins (IGFBPs), In the present study, serum and urine IGFBP (IGFBP-1, -2, and -3) and serum IGF-I and -II levels were measured by radioimmunoassay (RIA) in 27 patients with type 1 diabetes aged 9 to 48 years compared with 9 healthy subjects aged 10 to 28 years. The patients were divided into 3 groups according to the amount of albumin excreted in 24 hours. The macroalbuminuria group (>500 mg/24 h) had elevated serum IGFBP-1 and -2 and decreased IGF-I levels (P < .01 v normal controls). Serum IGFBP-3 and IGF-II were not different among the patient groups and controls (P > .05), The mean urinary IGFBP-1 was decreased in all 3 patient groups compared with the controls (P < .05). Urinary IGFBP-2 and IGFBP-3 were increased in patients with macroalbuminuria. Immunoblot analysis showed increased low-molecular-weight fragments of urinary IGFBP-2 in the poorly controlled diabetics, and direct evidence for increased urinary IGFBP-2 proteolytic activity could be demonstrated in both the microalbuminuric and macroalbuminuric groups. Low-molecular-weight fragments of urinary IGFBP-3 were also increased in both the microalbuminuric and macroalbuminuric groups, In conclusion, alterations of IGFBPs in urine and serum are related to metabolic control in diabetic patients, and there is an increase of urinary IGFBP-2 protease activity in poorly controlled diabetics. The changes in serum IGFBP concentrations (eg, increases in IGFBP-1 and IGFBP-2) may lead to alterations in the availability of IGF-I to peripheral tissues. Copyright (C) 2000 by W.B. Saunders Company.en_US
dc.description.sponsorshipNIA NIH HHS [AG02331] Funding Source: Medlineen_US
dc.identifier.doi10.1016/S0026-0495(00)80039-6
dc.identifier.endpage633en_US
dc.identifier.issn0026-0495
dc.identifier.issn1532-8600
dc.identifier.issue5en_US
dc.identifier.pmid10831174en_US
dc.identifier.scopus2-s2.0-0034069033en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage626en_US
dc.identifier.urihttps://doi.org/10.1016/S0026-0495(00)80039-6
dc.identifier.urihttps://hdl.handle.net/11616/93250
dc.identifier.volume49en_US
dc.identifier.wosWOS:000086971600014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofMetabolism-Clinical and Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHuman Amniotic-Fluiden_US
dc.subjectGene-Expressionen_US
dc.subjectSomatomedin-Cen_US
dc.subjectFactor Systemen_US
dc.subjectRat-Kidneyen_US
dc.subjectChildrenen_US
dc.subjectHormoneen_US
dc.subjectCellsen_US
dc.subjectMicroalbuminuriaen_US
dc.subjectPurificationen_US
dc.titleInsulin-like growth factor binding proteins (IGFBPs) in serum and urine and IGFBP-2 protease activity in patients with insulin-dependent diabetes mellitusen_US
dc.typeArticleen_US

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