Evaluation of right and left ventricular function using pulsed-wave tissue Doppler echocardiography in patients with subclinical hypothyroidism

Basit Öğe Kaydı
dc.authoridSahin, Ibrahim/0000-0002-6231-0034
dc.authoridTaskapan, Mehmet Cagatay/0000-0002-5273-4909
dc.authorwosidŞahin, İbrahim/HHY-8303-2022
dc.authorwosidturan, nedim/GXG-8035-2022
dc.authorwosidKutlusoy, Ergun/ABB-9017-2020
dc.authorwosidSahin, Ibrahim/ABI-6050-2020
dc.authorwosidTaskapan, Mehmet Cagatay/ABI-7747-2020
dc.contributor.authorKosar, F
dc.contributor.authorSahin, I
dc.contributor.authorTuran, N
dc.contributor.authorTopal, E
dc.contributor.authorAksoy, Y
dc.contributor.authorTaskapan, C
dc.date.accessioned2024-08-04T20:15:13Z
dc.date.available2024-08-04T20:15:13Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPrevious studies showed that subclinical hypothyroidism (SH) was associated with cardiovascular disorders, such as endothelial dysfunction, atherosclerosis and myocardial dysfunction. Only one study investigated left ventricular (LV) function using pulsed tissue Doppler echocardiography (TDE) in patients with SH. However, no study has used this technique in the identification of right ventricular (RV) function in these patients. We aimed to investigate the effect of SH on RV and LV function using TDE technique. The present study included 36 newly diagnosed SH patients and 28 healthy controls. For each subjects, serum free T-3 (FT3), free T-4 (FT4), total T-3 (TT3), total T-4 (TT4), TSH, peroxidase antibody (TPOab) and thyroglobulin antibody (TGab) levels were measured, and standard echocardiography and TDE were performed. In patients with SH, TSH levels were significantly higher, and TPOab and TGab levels were significantly higher when compared to healthy controls. TDE showed that the patients had significantly lower early diastolic mitral and tricuspid annular velocity (Ea) and early/late (Ea/Aa) diastolic mitral and tricuspid annular velocity ratio (p < 0.05, p < 0.05 and p < 0.001, p < 0.001, respectively), and significantly longer isovolumetric relaxation time (IRT) of left and right ventricles (p < 0.001 and p < 0.001, respectively). However, Aa, Sa, and isovolumetric contraction time (ICT) and ET (ejection time) of left and right ventricle did not significantly differ (p=ns for all). In addition, a negative correlation between TSH and TD-derived tricuspid Ea velocity and Ea/Aa ratio, and a positive correlation between TSH and IRT of right ventricle were observed. Our findings demonstrated that SH is associated with impaired RV diastolic function in addition to impaired LV diastolic function.en_US
dc.identifier.doi10.1007/BF03347553
dc.identifier.endpage710en_US
dc.identifier.issn1720-8386
dc.identifier.issue8en_US
dc.identifier.pmid16277166en_US
dc.identifier.scopus2-s2.0-31544481401en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage704en_US
dc.identifier.urihttps://doi.org/10.1007/BF03347553
dc.identifier.urihttps://hdl.handle.net/11616/94253
dc.identifier.volume28en_US
dc.identifier.wosWOS:000232814300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsubclinical hypothyroidismen_US
dc.subjectpulsed tissue Doppler echocardiographyen_US
dc.subjectright ventricular functionen_US
dc.subjectleft ventricular functionen_US
dc.titleEvaluation of right and left ventricular function using pulsed-wave tissue Doppler echocardiography in patients with subclinical hypothyroidismen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu