Effects of Ozone Therapy on Cyclophosphamide-induced Urinary Bladder Toxicity in Rats

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridKARAASLAN, MERVE GOKSIN/0000-0003-2645-808X
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.contributor.authorTasdemir, Seda
dc.contributor.authorTasdemir, Cemal
dc.contributor.authorVardi, Nigar
dc.contributor.authorAtes, Burhan
dc.contributor.authorTaslidere, Elif
dc.contributor.authorKaraaslan, Merve G.
dc.contributor.authorSapmaz, Hilal I.
dc.date.accessioned2024-08-04T20:37:28Z
dc.date.available2024-08-04T20:37:28Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: This study investigated the efficacy of ozone therapy (OT) in a rat model of cyclophosphamide-induced hemorrhagic cystitis (HC). Methods: Forty Wistar Albino male rats were divided into five groups: sham, OT, cyclophosphamide (CP), OT+CP and CP+OT. Hemorrhagic cystitis (HC) was induced by intraperitoneal (i.p) administration a single dose of 100 mg/kg CP. OT was performed once daily for three days. the CP+OT group received OT (0.2 mg/kg) i.p 24 h after CP administration. CP was injected to the OT+CP group the day after the third course of OT. All animals were killed four days after CP administration. Bladder injury and oxidative stress parameters were determined from tissue samples. Results: We found small, but non-statistically significant biochemical and histological changes in the animals treated with OT alone. CP administration induced cystitis, as manifested by a marked loss of urothelial cells, as well as hemorrhaging and edema in the bladder as determined by histopathological examination. It also caused a significant decrease in the endogenous antioxidant compound glutathione (GSH) and elevation of lipid peroxidation, and nitric oxide (NO) and myeloperoxidase (MPO) levels in the rats' urinary bladder tissue. OT was able to ameliorate these changes; however these effects were prominent in the CP+OT group when compared with the OT+CP group.: For example, the NO level in the CP+OT group was 68% of the OT+CP group (p < 0.05). Conclusion: OT prevented CP-induced urothelial damage by diminishing bladder oxidative stress, inflammation and NO levels. OT may help to ameliorate bladder damage induced by CP in the clinical setting.en_US
dc.identifier.endpageE17en_US
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue1en_US
dc.identifier.pmid23374601en_US
dc.identifier.scopus2-s2.0-84875030531en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageE9en_US
dc.identifier.urihttps://hdl.handle.net/11616/95984
dc.identifier.volume36en_US
dc.identifier.wosWOS:000318763600002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical and Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInduced Hemorrhagic Cystitisen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectAcute-Renal-Failureen_US
dc.subjectHyperbaric-Oxygenen_US
dc.subjectHuman-Leukocytesen_US
dc.subjectPathogenesisen_US
dc.subjectInductionen_US
dc.subjectInjuryen_US
dc.subjectAlphaen_US
dc.subjectIschemia/Reperfusionen_US
dc.titleEffects of Ozone Therapy on Cyclophosphamide-induced Urinary Bladder Toxicity in Ratsen_US
dc.typeArticleen_US

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