Synthesis, characterization and antitumor properties of novel silver(I) and gold(I) N-heterocyclic carbene complexes

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dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authoridÜstün, Elvan/0000-0002-0587-7261
dc.authoridEvren, Enes/0000-0002-7571-410X
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidYaşar, Şeyma/ABI-8055-2020
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidMANSOUR, Lamjed/AAO-6201-2020
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidMansour, Lamjed/U-3028-2017
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorCiftci, Osman
dc.contributor.authorEvren, Enes
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorKaloglu, Nazan
dc.contributor.authorTurkmen, Nese Basak
dc.contributor.authorYasar, Seyma
dc.date.accessioned2024-08-04T20:47:12Z
dc.date.available2024-08-04T20:47:12Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, two novel benzimidazolium salts consisting propane sulfonate order were integrated in high yields as N-heterocyclic carbene (NHC) precursors. The silver-NHC buildings were set up by responding 1-(2,2-dimethoxyahyl)-3-(propyl-3-sulfonate)benzimidazolium and 1-(2,2-diethoxyahyl)-3-(propyl-3-sulfonate)benzimidazolium with silver oxide on average state. Gold-NHC edifices were acquired by means of transmetallation of their silver precursors with [AuCl{S(CH3)(2)}]. The structures of all mixes were completely portrayed by spectroscopic techniques H-1 NMR, C-13{1H} NMR, IR and elemental and further analyzed by DFT/TDDFT strategies. IC50 values and cytotoxic impacts of these four complexes were controlled by the MTS put together examine with respect to three human cancer cell lines neuroblastoma (SHSY5Y), adenocarcinoma (HEP3B), and human fibroblasts (HF).en_US
dc.description.sponsorshipKing Saud University, Riyadh Saudi Arabia [RSP2019/75]; Technological and Scientific Research Council of Turkey (TUBITAK-MHESR) [114Z624]en_US
dc.description.sponsorshipThis work was funded by the Research Supporting Project (RSP2019/75), King Saud University, Riyadh Saudi Arabia and by the Technological and Scientific Research Council of Turkey (TUBITAK-MHESR 114Z624).en_US
dc.identifier.doi10.1016/j.ica.2020.119530
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-85081342078en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2020.119530
dc.identifier.urihttps://hdl.handle.net/11616/99218
dc.identifier.volume506en_US
dc.identifier.wosWOS:000522645200035en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofInorganica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectBenzimidazolium saltsen_US
dc.subjectSilver- and gold NHC complexesen_US
dc.subjectAntitumor activityen_US
dc.titleSynthesis, characterization and antitumor properties of novel silver(I) and gold(I) N-heterocyclic carbene complexesen_US
dc.typeArticleen_US

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