Effects of S(+) ketamine added to bupivacaine for spinal anaesthesia for prostate surgery in elderly patients

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dc.contributor.authorTogal, T
dc.contributor.authorDemirbilek, S
dc.contributor.authorKoroglu, A
dc.contributor.authorYapici, E
dc.contributor.authorErsoy, O
dc.date.accessioned2024-08-04T20:13:47Z
dc.date.available2024-08-04T20:13:47Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and objective: Intrathecal ketamine as the sole anaesthetic agent has demonstrated a lack of cardiovascular depression that should be of advantage in an elderly population. S(+) ketamine has three-times the analgesic potency of R(-) ketamine and its antinociceptive effects after intrathecal administration in rats are known. We decided to evaluate the effects of intrathecal S(+) ketamine added to a small dose of spinal bupivacaine in elderly patients undergoing transurethral prostate surgery. Methods: Forty males over 60 yr old, scheduled for transurethral prostate resection under spinal anaesthesia, were studied in a prospective, double-blinded, randomized way. Patients were allocated to receive either bupivacaine 10 mg or bupivacaine 7.5 mg combined with S(+) ketamine 0.1 mg kg(-1). Spinal block onset time, maximum sensory level, duration of blockade, haemodynamic variables, postoperative analgesic requirements and adverse events were recorded. Results: Onset times of motor and sensory block were shorter in the bupivacaine plus S(+) ketamine group. Incomplete motor block of the lower extremities was seen in 80% of the patients in bupivacaine plus S(+) ketamine group. Duration of complete motor block and spinal analgesia was shorter in the bupivacaine plus S(+) ketamine group. There was no significant difference in arterial pressure. Heart rate decreased after spinal anaesthesia in the bupivacaine plus S(+) ketamine group and was significantly lower until the end of anaesthesia. The incidence of adverse effects was not different between groups. Conclusions: Intrathecal S(+) ketamine administered with a low dose of bupivacaine provides shorter motor and sensory block onset time, shorter duration of action and less motor blockade in elderly males.en_US
dc.identifier.doi10.1017/S0265021504003059
dc.identifier.endpage197en_US
dc.identifier.issn0265-0215
dc.identifier.issue3en_US
dc.identifier.pmid15055891en_US
dc.identifier.scopus2-s2.0-1542378292en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage193en_US
dc.identifier.urihttps://doi.org/10.1017/S0265021504003059
dc.identifier.urihttps://hdl.handle.net/11616/93847
dc.identifier.volume21en_US
dc.identifier.wosWOS:000220349000005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGreenwich Medical Media Ltden_US
dc.relation.ispartofEuropean Journal of Anaesthesiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectanaesthesia, spinalen_US
dc.subjectanaesthetics, local, bupivacaineen_US
dc.subjectanalgesics, non-narcotic, ketamineen_US
dc.subjectisomerism, stereoisomerismen_US
dc.titleEffects of S(+) ketamine added to bupivacaine for spinal anaesthesia for prostate surgery in elderly patientsen_US
dc.typeArticleen_US

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