Micronucleus frequency in peripheral blood lymphocytes and exfoliated buccal cells of untreated cancer patients.

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dc.authorscopusid57196518026
dc.authorscopusid7007088980
dc.authorscopusid6604070029
dc.contributor.authorYildirim I.H.
dc.contributor.authorYesilada E.
dc.contributor.authorYologlu S.
dc.date.accessioned2024-08-04T19:59:06Z
dc.date.available2024-08-04T19:59:06Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSome genetic diseases may increase the cellular instability. Since most human tumors have some genetic base, this study was undertaken for the genetic instability in cancer patients by micronucleus analysis, a mutation-screening test, which is more practical and economic technique than metaphase analysis carried out for chromosomal aberrations. Genetic changes were assessed in untreated cancer patients (lung, stomach and colon cancer) by different genotoxical screening methods; the cytokinesis-block micronucleus test and the buccal mucosa cell micronucleus test. The evaluation of micronuclei number in peripheral blood lymphocytes and buccal cells showed a genomic instability in somatic cells. There was a significant increase in the number of micronuclei in cancer patients prior to the initiation of chemotherapy, and/or radiotherapy compared with healthy human subjects. Furthermore, there was no significant difference between smokers and non-smoking groups or male and female groups. These results suggest that cancer in humans is characterized by an increase of chromosomal damage and thus, the micronucleus assay carried out here may be useful in routine cytogenetic studies of cancer.en_US
dc.identifier.endpage710en_US
dc.identifier.issn0016-6758
dc.identifier.issue5en_US
dc.identifier.pmid16808251en_US
dc.identifier.scopus2-s2.0-33745713553en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage705en_US
dc.identifier.urihttps://hdl.handle.net/11616/90396
dc.identifier.volume42en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofGenetikaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectarticleen_US
dc.subjectfemaleen_US
dc.subjectgeneticsen_US
dc.subjecthumanen_US
dc.subjectlymphocyteen_US
dc.subjectmaleen_US
dc.subjectmicronucleus testen_US
dc.subjectmiddle ageden_US
dc.subjectmouth mucosaen_US
dc.subjectneoplasmen_US
dc.subjectultrastructureen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectLymphocytesen_US
dc.subjectMaleen_US
dc.subjectMicronucleus Testsen_US
dc.subjectMiddle Ageden_US
dc.subjectMouth Mucosaen_US
dc.subjectNeoplasmsen_US
dc.titleMicronucleus frequency in peripheral blood lymphocytes and exfoliated buccal cells of untreated cancer patients.en_US
dc.typeArticleen_US

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