THE EFFECTS OF FIBROBLAST GROWTH FACTOR-2 AND OZONE THERAPY ON ACUTE KIDNEY INJURY IN RENAL ISCHEMIA/REPERFUSION INJURY
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Parlar Scientific Publications (P S P)
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Renal ischemia/reperfusion (I/R) injury is the most common risk factor for AKI. The study aimed to investigate the effects of FGF-2 and ozone applications on the kidneys of rats with hypoxic-ischemia. Six groups were formed with seven pups in each: sham control, ischemia-reperfusion (I/R), FGF-2(10 FGF-2(20 mu l/ml), ozone (25 mg/kg), and ozone (50 mg/kg) groups. After the tissue processing and staining of the kidney samples, the renal injury was scored and data were analyzed. Manifestations of collapse and sclerotic changes in the glomeruli, observations of collapse in the Bowman's space, excessive accumulation in the ultrafiltrate and dilatation was noted in the I/R group. The average diameter of the glomeruli and the scores of injury were significantly different between the I/R and FGF20 groups and the I/R and Ozone 50 groups (p<0.05). The histopathologic assessment showed that the treatment with FGF-2 or ozone had renoprotective effects against renal damage caused by I/R in a dose-dependent manner. This study may discover a new therapeutic strategy for the treatment of AKI based on specified pathogenesis. This study found the FGF-2 and ozone applications to he beneficial for the treatment of AKI at the cellular level with certain doses.
Açıklama
Anahtar Kelimeler
Ischemia-reperfusion, FGF-2, ozone applications, acute kidney injury
Kaynak
Fresenius Environmental Bulletin
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
29
Sayı
12A
