THE EFFECTS OF FIBROBLAST GROWTH FACTOR-2 AND OZONE THERAPY ON ACUTE KIDNEY INJURY IN RENAL ISCHEMIA/REPERFUSION INJURY

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dc.authoridBAHAR, LEYLA/0000-0002-6910-6167;
dc.authorwosidBAHAR, LEYLA/Y-3908-2019
dc.authorwosidCelik, Yalcin/AAA-4342-2021
dc.authorwosiderden ertürk, sema/O-9225-2015
dc.contributor.authorBahar, Leyla
dc.contributor.authorGul, Mehmet
dc.contributor.authorResitoglu, Bora
dc.contributor.authorCelik, Yalcin
dc.contributor.authorErturk, Sema Erden
dc.contributor.authorGul, Semir
dc.date.accessioned2024-08-04T21:02:02Z
dc.date.available2024-08-04T21:02:02Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRenal ischemia/reperfusion (I/R) injury is the most common risk factor for AKI. The study aimed to investigate the effects of FGF-2 and ozone applications on the kidneys of rats with hypoxic-ischemia. Six groups were formed with seven pups in each: sham control, ischemia-reperfusion (I/R), FGF-2(10 FGF-2(20 mu l/ml), ozone (25 mg/kg), and ozone (50 mg/kg) groups. After the tissue processing and staining of the kidney samples, the renal injury was scored and data were analyzed. Manifestations of collapse and sclerotic changes in the glomeruli, observations of collapse in the Bowman's space, excessive accumulation in the ultrafiltrate and dilatation was noted in the I/R group. The average diameter of the glomeruli and the scores of injury were significantly different between the I/R and FGF20 groups and the I/R and Ozone 50 groups (p<0.05). The histopathologic assessment showed that the treatment with FGF-2 or ozone had renoprotective effects against renal damage caused by I/R in a dose-dependent manner. This study may discover a new therapeutic strategy for the treatment of AKI based on specified pathogenesis. This study found the FGF-2 and ozone applications to he beneficial for the treatment of AKI at the cellular level with certain doses.en_US
dc.identifier.endpage11150en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue12Aen_US
dc.identifier.startpage11143en_US
dc.identifier.urihttps://hdl.handle.net/11616/104401
dc.identifier.volume29en_US
dc.identifier.wosWOS:000629180800011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-reperfusionen_US
dc.subjectFGF-2en_US
dc.subjectozone applicationsen_US
dc.subjectacute kidney injuryen_US
dc.titleTHE EFFECTS OF FIBROBLAST GROWTH FACTOR-2 AND OZONE THERAPY ON ACUTE KIDNEY INJURY IN RENAL ISCHEMIA/REPERFUSION INJURYen_US
dc.typeArticleen_US

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