Compatible ABO mismatch and liver transplantation: A single center's experience

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dc.authorscopusid6701920045
dc.authorscopusid7004015279
dc.authorscopusid57507949000
dc.authorscopusid14029289800
dc.authorscopusid7202463116
dc.authorscopusid7003603265
dc.authorscopusid7005671397
dc.contributor.authorAladag M.
dc.contributor.authorGurakar A.
dc.contributor.authorCamci C.
dc.contributor.authorYong Y.
dc.contributor.authorWright H.
dc.contributor.authorNour B.
dc.contributor.authorSebastian A.
dc.date.accessioned2024-08-04T20:02:06Z
dc.date.available2024-08-04T20:02:06Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: The current shortage of suitable donor organs and clinical urgency can lead to implanting grafts from ABO-mismatched donors. One-year graft survival rates for patients in this scenario have been reported as ranging between 25% and 75% less than those for ABO-identical or ABO-compatible grafts. We review and compare our experiences with transplanting ABO-identical and ABO-compatible mismatched livers. Materials and Methods: Considering orthotopic liver transplantation (OLTx), 520 were performed at our institution between November 1992 and May 2003, 55 of which were ABO-compatible mismatched transplants. We retrospectively reviewed the data and compared patient and graft survival rates. Results: Overall 1-month and 1-, 5-, and 10-year patient survival rates among identical (group 1) and mismatched (group 2) groups were 97% and 91%, 90%, and 88.5%, and 79%, and 74%, 66%, and 65%, respectively. No significant difference existed between the 2 groups (P > .05). Similarly, 1-month, and 1-, 5-, and 10-year graft survival rates among groups 1 and 2 were 96% and 87%, 89% and 83%, 78% and 71% and 66% and 59%, respectively; these were not significant either (P > .05). All of the patients in the mismatched group had a high status according to the United Network for Organ Sharing (UNOS). Only 1 person received an incompatible mismatched graft (B to A), which subsequently developed primary nonfunction. Conclusions: ABO-compatible mismatch OLTx is unavoidable given the current state of organ shortage. Our results suggest that this type of OLTx can be performed with minimal risk among patients who require urgent transplantation and have high rankings according to the UNOS and the model for end-stage liver disease (MELD) system. Copyright © Başkent University 2006 Printed in Turkey. All Rights Reserved.en_US
dc.identifier.endpage469en_US
dc.identifier.issn1304-0855
dc.identifier.issue1en_US
dc.identifier.pmid16827645en_US
dc.identifier.scopus2-s2.0-33745626751en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage467en_US
dc.identifier.urihttps://hdl.handle.net/11616/91425
dc.identifier.volume4en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofExperimental and Clinical Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectABO-compatible mismatchen_US
dc.subjectIncompatible mismatchen_US
dc.subjectOrthotopic liver transplantationen_US
dc.titleCompatible ABO mismatch and liver transplantation: A single center's experienceen_US
dc.typeReview Articleen_US

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