Role of Synthesized Organoselenium Compounds on Protection of Rat Erythrocytes from DMBA-Induced Oxidative Stress

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dc.authoridYılmaz, İsmet/0000-0002-7204-1050
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authoridCetinkaya, Bekir/0000-0002-4551-8650
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidYılmaz, ismet/AAG-8946-2019
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorYilmaz, Ismet
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorAtes, Burhan
dc.contributor.authorGok, Yetkin
dc.contributor.authorCetinkaya, Bekir
dc.date.accessioned2024-08-04T20:31:12Z
dc.date.available2024-08-04T20:31:12Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractFormation of free radicals is not limited to normal cellular process but also occur upon exposure to certain chemicals (polycyclic aromatic hydrocarbon, cadmium, lead, etc.), cigarette smoke, radiation, and high-fat diet. Free-radical damage is an important factor in many pathological and toxicological processes. Selenium, an essential micronutrient, is a associated with antioxidant functions, physiological defense mechanisms against different diseases including several types of cancers. Search for new selenium compounds with more chemopreventive activities and less toxicities are in progress. In addition, there has been a growing interest in the synthesis of organoselenium compounds with respect to their use in enzymology and bioorganic chemistry. In the present study, adult female Wistar rats were treated with 7,12-dimethylbenz[a]anthracene (DMBA) and the organoselenium compounds [1-isopropyl-3-methylbenzimidazole-2-selenone (Se I) and 1, 3-di-p-methoxybenzylpyrimidine-2-selenone (Se II)] in determined doses. The protective effects of synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in antioxidant enzyme (superoxide dismutase, glutathione peroxidase (GSH-Px), catalase (CAT), glutathione reductase (GR)) activities, total GSH, and malondialdehyde (MDA) levels of rat erythrocyte were investigated. The DMBA-treated group exhibited significant decreases in the levels of erythrocyte GSH-Px, CAT, and GR activities, an increase in MDA levels, and a decrease in total GSH level compared to the control. Se I and Se II fully or partially restored enzyme activity. Lipid peroxidation was also decreased in Se-I- and Se-II-treated groups.en_US
dc.identifier.doi10.1007/s12011-008-8262-0
dc.identifier.endpage175en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid18974938en_US
dc.identifier.scopus2-s2.0-65449148261en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage167en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-008-8262-0
dc.identifier.urihttps://hdl.handle.net/11616/94795
dc.identifier.volume128en_US
dc.identifier.wosWOS:000264463000009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectErythrocyteen_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.subjectSynthetic organoselenium compoundsen_US
dc.titleRole of Synthesized Organoselenium Compounds on Protection of Rat Erythrocytes from DMBA-Induced Oxidative Stressen_US
dc.typeArticleen_US

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