Hydrocortisone may act through the angiotensin II receptor-2 level in patients with catecholamine-resistant septic shock

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dc.authoridbicakcioglu, murat/0000-0001-9101-6857
dc.authorwosidBULUT, Nilüfer/HJH-8128-2023
dc.authorwosidbicakcioglu, murat/AAA-8149-2022
dc.contributor.authorBaykan, Seyma
dc.contributor.authorBicakcioglu, Murat
dc.contributor.authorBulut, Nilufer
dc.contributor.authorYucel, Neslihan
dc.contributor.authorErsoy, Yasemin
dc.contributor.authorUysal, Nermin Kibrislioglu
dc.contributor.authorOzer, Ayse B.
dc.date.accessioned2024-08-04T20:53:41Z
dc.date.available2024-08-04T20:53:41Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: This study aimed to compare the serum angiotensin II and its receptor levels (AT1, AT2) in septic patients with catecholamine-responsive or resistant. The effect of hydrocortisone treatment on angiotensin II levels in the catecholamine-resistant septic patients was evaluated.METHODS: This prospective observational study enrolled 40 patients diagnosed with septic shock based on sepsis-3 cri-teria. Patients were divided into two groups according to the noradrenalin infusion rate required to keep the mean arterial pressure above 65 mmHg: control group and hydrocortisone group (control group: below 0.5 mu g/kg/min, hydrocortisone group: above 0.5 mu g/kg/min). Serum angiotensin II, AT1, AT2 levels were measured at the time of diagnosis (A), one hour after hydrocortisone treatment (B), and three days later (C).RESULTS: In the catecholamine-resistant group, angiotensin II and AT1 levels were higher than the catecholamine-responder group in all periods. The sensitivity and specificity of AT-1 was observed to be high in all periods. AT2 levels decreased after hydrocortisone treatment in the catecholamine-resistant group and cut-off value was found 11%.CONCLUSIONS: It was concluded that angiotensin II and AT1 can be used as a biomarker of refractory septic shock and hydrocortisone may provide their blood pressure correcting effect by reducing AT2 level in these patients. AT2 can be a therapeutic target in the catecholamine-resistant septic shock patients.en_US
dc.identifier.doi10.23736/S0375-9393.22.16766-0
dc.identifier.endpage305en_US
dc.identifier.issn0375-9393
dc.identifier.issn1827-1596
dc.identifier.issue4en_US
dc.identifier.pmid36287393en_US
dc.identifier.scopus2-s2.0-85153975554en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage298en_US
dc.identifier.urihttps://doi.org/10.23736/S0375-9393.22.16766-0
dc.identifier.urihttps://hdl.handle.net/11616/101325
dc.identifier.volume89en_US
dc.identifier.wosWOS:000988639700007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofMinerva Anestesiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiotensin IIen_US
dc.subjectHydrocortisoneen_US
dc.subjectShocken_US
dc.subjectsepticen_US
dc.titleHydrocortisone may act through the angiotensin II receptor-2 level in patients with catecholamine-resistant septic shocken_US
dc.typeArticleen_US

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