Effects of carbon dioxide pneumoperitoneum on free radical formation in lung and liver tissues

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dc.authoridYesilada, Ozfer/0000-0003-0038-6575
dc.authoridAsma, Dilek/0000-0002-3866-3016
dc.authoridOzmen, Murat/0000-0003-4378-0839
dc.authorwosidYesilada, Ozfer/ABI-1335-2020
dc.authorwosidOZMEN, MURAT/A-4874-2009
dc.authorwosidAsma, Dilek/AAA-5294-2021
dc.contributor.authorSare, M
dc.contributor.authorHamamci, D
dc.contributor.authorYilmaz, I
dc.contributor.authorBirincioglu, M
dc.contributor.authorMentes, BB
dc.contributor.authorÖzmen, M
dc.contributor.authorYesilada, Ö
dc.date.accessioned2024-08-04T20:12:21Z
dc.date.available2024-08-04T20:12:21Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.descriptionEurosurgery Congress -- JUN 20-24, 2000 -- ISTANBUL, TURKEYen_US
dc.description.abstractBackground: The purpose of this study was to investigate the possible effects of carbon dioxide (CO2) pneumoperitoneum on free radical formation and lipid peroxidation in the lung and liver tissues of rats. Methods: For this study, 50 male Sprague-Dawley rats were divided into five equal groups: control (group 1); sham operation (group 2): 5, 10, or 15 mmHg (group 3, 4, or 5) pneumoperitoneum with CO2 groups. At the end of the procedures, the rats were killed, and perfusion was performed via vena jugularis with cold Ringer's lactate. After the perfusion procedure, the lung and liver were harvested, and the supernatant fractions of the lungs and livers were assayed for superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA). Results: Both the lung and liver CAT activities were elevated consistently and significantly in the order of the study groups. as compared with the previous groups (p < 0.01 for all comparisons). The lung and liver SOD levels were elevated in groups 4 and 5, as compared with the other groups (p < 0.05). The lung MDA was significantly higher in groups 3 and 4, but not in group 5. Significant elevation in liver MDA was noted only in the 5-mmHg pneumoperitoneum group (p < 0.05). Conclusions: These results indicate that CO2 pneumoperitoneum applied with 5, 10, or 15 mmHg pressure increases the formation of free oxygen radicals, which is counterbalanced by increased SOD and CAT activities of the lung and liver tissues. This effect of CO2 pneumoperitoneum on free radicals and lipid peroxidation appears to be pressure dependent in rats. The mechanism underlying this pressure dependency is still under investigation.en_US
dc.identifier.doi10.1007/s004640090103
dc.identifier.endpage192en_US
dc.identifier.issn0930-2794
dc.identifier.issn1432-2218
dc.identifier.issue1en_US
dc.identifier.pmid11961637en_US
dc.identifier.scopus2-s2.0-0036135972en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage188en_US
dc.identifier.urihttps://doi.org/10.1007/s004640090103
dc.identifier.urihttps://hdl.handle.net/11616/93384
dc.identifier.volume16en_US
dc.identifier.wosWOS:000173060500045en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofSurgical Endoscopy and Other Interventional Techniquesen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectlaparoscopic surgeryen_US
dc.subjectcarbon dioxideen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectcatalaseen_US
dc.subjectmalondialdehydeen_US
dc.subjectliveren_US
dc.subjectlungen_US
dc.titleEffects of carbon dioxide pneumoperitoneum on free radical formation in lung and liver tissuesen_US
dc.typeConference Objecten_US

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