The historical factors associated with the true nonsteroidal anti-inflammatory drug hypersensitivity in children

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dc.contributor.authorSayan, Yekbun Gamze
dc.contributor.authorTopal, Erdem
dc.date.accessioned2024-08-04T19:42:37Z
dc.date.available2024-08-04T19:42:37Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: To determine the frequency of true NSAIDs hypersensitivity in children and whether there were any parameters in the history to predict NSAIDs hypersensitivity.Material and Methods: Children who applied to outpatient clinic with a history suggesting NSAID hypersensitivity were evaluated by a pediatric allergist. The confirmed NSAID hypersensitivity was found by skin test and/or oral provocation tests.Results: Fifty patients who were admitted with a suspicion of immediate-type reaction to NSAID were included in the study. The median age of the patients was 6 (1-16) years old and 28 (56%) of the patients were male. We performed skin tests with the suspected NSAID in 28 (56%) patients. Of these, 2 had positive results. Provocation tests were performed on 48 patients whose skin tests were negative or skin tests were not available. During the provocation tests, 11 patients (22%) developed reaction. Clinical parameters inhistory were evaluated by using univariate analysis; the age of child ? 6 years old (p=0.006), family history of NSAIDs hypersensitivity (p=0.039), presence of multiple immediate type NSAIDs hypersensitivity in history (p=0.01), emergence of reaction within an hour (p=0.004) were found as significant factors to predicted true NSAID hypersensitivity in history.Conclusions: The diagnosis of immediate type NSAIDs hypersensitivity was not done by clinical history, oral provocation tests should be done for true diagnosis. However, the age of child ? 6 years old, family history of NSAIDs hypersensitivity, presence of multiple immediate type NSAIDs hypersensitivity in history, emergence of reaction within an hour in history can predict the true NSAIDs hypersensitivityen_US
dc.identifier.doi10.5455/annalsmedres.2018.05.087
dc.identifier.endpage484en_US
dc.identifier.issn2636-7688
dc.identifier.issue3en_US
dc.identifier.startpage481en_US
dc.identifier.trdizinid285702en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2018.05.087
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/285702
dc.identifier.urihttps://hdl.handle.net/11616/88515
dc.identifier.volume25en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe historical factors associated with the true nonsteroidal anti-inflammatory drug hypersensitivity in childrenen_US
dc.typeArticleen_US

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