The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: Role of matrix metalloproteinases in tumor progression and prognosis

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dc.authorscopusid8571730800
dc.authorscopusid26425322400
dc.authorscopusid24504050900
dc.authorscopusid24780735400
dc.authorscopusid23018615700
dc.authorscopusid6601982966
dc.contributor.authorKirimlio?lu H.
dc.contributor.authorTürkmen I.
dc.contributor.authorBaşsüllü N.
dc.contributor.authorDirican A.
dc.contributor.authorKarada? N.
dc.contributor.authorKirimlio?lu V.
dc.date.accessioned2024-08-04T20:01:02Z
dc.date.available2024-08-04T20:01:02Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/aims: Carcinomas of the biliary tree are rare tumors of the gastrointestinal tract, with an increasing incidence in recent years. Biliary neoplasms are classified into intra- and extrahepatic cholangiocarcinoma (Klatskin tumor, middle and distal extrahepatic tumors), gallbladder adenocarcinoma, and ampullary carcinoma. We aimed to determine the expression profile of matrix metalloproteinase (MMP)-2, MMP-9 and MMP-14 in the biliary neoplasms classified according to their localization and the relation with the prognosis. Methods: Ten gallbladder adenocarcinoma, 8 distal bile duct carcinomas (distal cholangiocarcinoma), 8 Klatskin tumors, 8 intrahepatic cholangiocarci-nomas and 10 ampullary carcinomas were included in the study. The immunohistochemical expression of MMP-2, MMP-9 and MMP-14 was detected in the nontumoral, metaplastic, dysplastic and tumoral epithelia. The tumor differentiation, angiolymphatic and perineural invasion of the tumor, and presence of lymph node and distant metastasis were determined. Survey of the patients was noted from the patient follow-up data. Results: The nontumoral epithelia of the gallbladder, intrahepa- tic ducts, and Klatskin tumor did not express MMP-'. MMP-2 expression was detected in the distal part of the biliary ducts, in 75% (6/18) of cases and in the nontumoral epithelia of the ampullary region in 50% (5/10) of cases. The metaplastic and dysplastic epithelia were positively stained in all of the gallbladder adenocarcinoma, distal cholangiocarci- noma and ampullary tumors. In the intrahepatic cholangiocarcinoma, the hepatocytes were positively stained but the infiltrative tumors were spared. Klatskin tumors were also not stained with MMP-2. The gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary carcinomas expressed MMP-2 in 30%, 37% and 40% of the cases, respectively. MMP-9 and MMP-14 were expressed in normal, metaplastic, and dysplastic epithelium and tumoral cells in all of the cases of the groups. Expressions of MMPs were higher in subjects with neural invasion, but there was no correlation between MMP expression and tumor differentiation or angiolymphatic invasion. Conclusions: When tumors of the biliary system are divided as intrahepatic and extrahepatic cholangiocar- cinomas, MMP-2 expression was present in the extrahepatic cholangio- carcinomas including gallbladder carcinomas. Like the intrahepatic cholangiocarcinoma, Klatskin tumors also did not express MMP-2. This can be related with its characteristic growth pattern. MMP-9 and MMP- 14 were present in metaplasia, dysplasia carcinoma sequence in all of the bile tract tumors, suggesting that MMPs play an important role in carcinogenesis. The higher expression of the MMPs with neural invasion suggests the significant role of those tumors in the invasion activity.en_US
dc.identifier.endpage47en_US
dc.identifier.issn1300-4948
dc.identifier.issue1en_US
dc.identifier.pmid19330734en_US
dc.identifier.scopus2-s2.0-63449130951en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage41en_US
dc.identifier.urihttps://hdl.handle.net/11616/91211
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiliary neoplasmsen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMatrix metalloproteinasesen_US
dc.titleThe expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: Role of matrix metalloproteinases in tumor progression and prognosisen_US
dc.typeArticleen_US

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