Adipose-derived stem cells in the treatment of hepatobiliary diseases and sepsis

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authorwosidcicek, egemen/HJY-0590-2023
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidSatilmis, Basri/JBR-9078-2023
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidSatilmis, Basri/C-5176-2019
dc.contributor.authorSatilmis, Basri
dc.contributor.authorCicek, Gizem Selen
dc.contributor.authorCicek, Egemen
dc.contributor.authorAkbulut, Sami
dc.contributor.authorSahin, Tevfik Tolga
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:51:57Z
dc.date.available2024-08-04T20:51:57Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDetermination of the mesenchymal stem cells is one of the greatest and most exciting achievements that tissue engineering and regenerative medicine have achieved. Adipose-derived mesenchymal stem cells (AD-MSC) are easily isolated and cultured for a long time before losing their stem cell characteristics, which are self-renewal and pluripotency. AD-MSC are mesenchymal stem cells that have pluripotent lineage characteristics. They are easily accessible, and the fraction of stem cells in the adipose tissue lysates is highest among all other sources of mesenchymal stem cells. It is also HLA-DR negative and can be transplanted allogenically without the need for immunosuppression. These advantages have popularized its use in many fields including plastic reconstructive surgery. However, in the field of hepatology and liver transplantation, the progress is slower. AD-MSC have the potential to modulate inflammation, ameliorate ischemia-reperfusion injury, and support liver and biliary tract regeneration. These are very important for the treatment of various hepatobiliary diseases. Furthermore, the anti-inflammatory potential of these cells has paramount importance in the treatment of sepsis. We need alternative therapeutic approaches to treat end-stage liver failure. AD-MSC can provide a means of therapy to bridge to definitive therapeutic alternatives such as liver transplantation. Here we propose to review theoretic applications of AD-MSC in the treatment of hepatobiliary diseases and sepsis.en_US
dc.identifier.doi10.12998/wjcc.v10.i14.4348
dc.identifier.issn2307-8960
dc.identifier.issue14en_US
dc.identifier.pmid35663078en_US
dc.identifier.scopus2-s2.0-85130324180en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.12998/wjcc.v10.i14.4348
dc.identifier.urihttps://hdl.handle.net/11616/100660
dc.identifier.volume10en_US
dc.identifier.wosWOS:000804981300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal of Clinical Casesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdipose-derived stem cellsen_US
dc.subjectHepatobiliary diseasesen_US
dc.subjectSepsisen_US
dc.subjectMesenchymal stem cellsen_US
dc.subjectTheoretic applicationen_US
dc.titleAdipose-derived stem cells in the treatment of hepatobiliary diseases and sepsisen_US
dc.typeReview Articleen_US

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