Does Chrysin prevent severe lung damage in Hyperoxia-Induced lung injury Model?

Basit Öğe Kaydı
dc.authoridturgut, hatice/0000-0002-0490-7852
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridAslan, Mehmet/0000-0001-5710-6592
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authorwosidturgut, hatice/IZQ-4154-2023
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.authorwosidAslan, Mehmet/AEL-7823-2022
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorOzdemir, Ramazan
dc.contributor.authorGokce, Ismail Kursat
dc.contributor.authorTaslidere, Asli Cetin
dc.contributor.authorTanbek, Kevser
dc.contributor.authorGul, Cemile Ceren
dc.contributor.authorSandal, Suleyman
dc.contributor.authorTurgut, Hatice
dc.date.accessioned2024-08-04T20:50:28Z
dc.date.available2024-08-04T20:50:28Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Oxidative stress and inflammation play a critical role in the etiopathogenesis of bronchopulmonary dysplasia (BPD). The aim of this study was to evaluate the preventive effect of Chrysin (CH), an antioxidant, antiinflammatory, antiapoptotic and antifibrotic drug, on hyperoxia-induced lung injury in a neonatal rat model. Methods: Forty infant rats were divided into four groups labeled the Control, CH, BPD, and BPD + CH. The control and CH groups were kept in a normal room environment, while the BPD and BPD + CH groups were kept in a hyperoxic (90-95%) environment. At the end of the study, lung tissue was evaluated with respect to apoptosis, histopathological damage and alveolar macrophage score as well as oxidant capacity, antioxidant capacity, and inflammation. Results: Compared to the BPD + CH and control groups, the lung tissues of the BPD group displayed substantially higher levels of MDA, TOS, TNF-alpha, and IL-1 beta (p < 0.05). While the BPD + CH group showed similar levels of TNF-alpha, and IL-1 beta as the control group, MDA and TOS levels were higher than the control group, and significantly lower than the BPD group (p < 0.05). The BPD group exhibited considerably lower levels of TAS, SOD, GSH, and GSHPx in comparison to the control group (p < 0.05). The BPD and BPD + CH groups exhibited higher mean scores of histopathological damage and alveolar macrophage when compared to the control and CH groups (p <= 0.0001). Both scores were found to be lower in the BPD + CH group in comparison to the BPD group (p <= 0.0001). The BPD + CH group demonstrated a significantly lower average of TUNEL and caspase-3 positive cells than the BPD group. Conclusion: We found that prophylaxis with CH results in lower histopathological damage score and reduces apoptotic cell count, inflammation and oxidative stress while increasing anti-oxidant capacity.en_US
dc.description.sponsorshipResearch Fund of the Inonu Uni-versity [TSA-2018-1384]en_US
dc.description.sponsorshipThis work was supported by the Research Fund of the Inonu Uni-versity (Project Number: TSA-2018-1384) .en_US
dc.identifier.doi10.1016/j.intimp.2021.108033
dc.identifier.issn1567-5769
dc.identifier.issn1878-1705
dc.identifier.pmid34343938en_US
dc.identifier.scopus2-s2.0-85111657954en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.intimp.2021.108033
dc.identifier.urihttps://hdl.handle.net/11616/100088
dc.identifier.volume99en_US
dc.identifier.wosWOS:000693562800004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Immunopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBronchopulmonary Dysplasiaen_US
dc.subjectChronic Lung Diseaseen_US
dc.subjectChrysinen_US
dc.subjectNewbornen_US
dc.subjectAntioxidanten_US
dc.subjectAntiinflammatoryen_US
dc.subjectHyperoxia-Induced Lung Injuryen_US
dc.titleDoes Chrysin prevent severe lung damage in Hyperoxia-Induced lung injury Model?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu