Synthesis, Characterization, Antimicrobial Properties, and Antioxidant Activities of Silver-N-Heterocyclic Carbene Complexes

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dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authorwosidOZDEMIR, ISMAIL/KVY-3420-2024
dc.authorwosidMansour, Lamjed/AAD-8613-2019
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.contributor.authorBensalah, Donia
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorGatri, Rafik
dc.contributor.authorMansour, Lamjed
dc.contributor.authorHamdi, Naceur
dc.date.accessioned2024-08-04T20:53:46Z
dc.date.available2024-08-04T20:53:46Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe emergence of antimicrobial resistance has become a major handicap in the fight against bacterial infections, prompting researchers to develop new, more effective, and multimodal alternatives. Silver and its complexes have long been used as antimicrobial agents in medicine because of their lack of resistance to silver, their low potency at low concentrations, and their low toxicity compared to most commonly used antibiotics. N-Heterocyclic carbenes (NHCs) are widely used for coordination of transition metals, mainly in catalytic chemistry. In this study, several N-alkylated benzimidazolium salts 2a-j were synthesized. Then, the N-heterocyclic carbene (NHC) precursor was treated with Ag2O to give silver (I) NHC complexes (3a-j) at room temperature in dichloromethane for 48 h. Ten new silver-NHC complexes were fully characterized by nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT-IR), elemental analysis, and LC-MSMS (for complexes) techniques. The antibacterial and antioxidant activities of salt 2 and its silver complex 3 were evaluated. All of these complexes were more effective against bacterial strains than comparable ligands. With MIC values ranging from 6.25 to 100 g/ml, the Ag-NHC complex effectively showed strong antibacterial activity. Antioxidant activity was also tested using conventional techniques, such as 2, 2-diphenyl-1-picrylhydrazine (DPPH) and hydrogen peroxide scavenging assays. In DPPH and ABTS experiments, compounds 3a, 3b, 3c, 3e, 3g, and 3i showed significant clearance.en_US
dc.description.sponsorshipKing Saud University, Riyadh, Saudi Arabia [RSP2023R75]en_US
dc.description.sponsorshipAcknowledgmentsThe authors extended their appreciation to the Researchers Supporting Project number (RSP2023R75), King Saud University, Riyadh, Saudi Arabia.en_US
dc.identifier.doi10.1155/2023/3066299
dc.identifier.issn1565-3633
dc.identifier.issn1687-479X
dc.identifier.pmid37274082en_US
dc.identifier.scopus2-s2.0-85161325707en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1155/2023/3066299
dc.identifier.urihttps://hdl.handle.net/11616/101391
dc.identifier.volume2023en_US
dc.identifier.wosWOS:000998991500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofBioinorganic Chemistry and Applicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSilver(I)-Carbene Complexesen_US
dc.subjectBenzimidazolium Saltsen_US
dc.subjectAnticancer Activityen_US
dc.subjectCrystal-Structureen_US
dc.subjectNatural-Productsen_US
dc.subjectNhcen_US
dc.subjectPrecursorsen_US
dc.subjectResistanceen_US
dc.titleSynthesis, Characterization, Antimicrobial Properties, and Antioxidant Activities of Silver-N-Heterocyclic Carbene Complexesen_US
dc.typeArticleen_US

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