Protective effect of benfotiamine on methotrexate induced gastric damage in rats

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dc.authoriderdogan, mehmet ali/0000-0002-1713-5695
dc.authoridKOC, SULEYMAN/0000-0001-7794-4518
dc.authoridErdogan, Esra/0000-0003-1626-6033
dc.authorwosiderdogan, mehmet ali/ABI-4675-2020
dc.authorwosiderdoğan, esra/JTV-5844-2023
dc.contributor.authorKoc, S.
dc.contributor.authorErdogan, M. A.
dc.contributor.authorErdogan, E.
dc.contributor.authorYalcin, A.
dc.contributor.authorTurk, A.
dc.contributor.authorErdogan, M. M.
dc.date.accessioned2024-08-04T20:49:08Z
dc.date.available2024-08-04T20:49:08Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMethotrexate (MTX) is widely used for treating cancers and inflammatory diseases; it is a potential anti-metabolite and folate antagonist. We investigated potential protective effects of benfotiamine on MTX damage. We used a rat model of MTX induced gastric injury to assess changes in gastric histopathology, oxidative stress and visfatin levels due to MTX treatment. Rats were divided into four groups: an untreated control group, an MTX group treated with a single dose of MTX, a benfotiamine group treated with benfotiamine daily for two weeks, and a benfotiamine + MTX group treated with a single dose of MTX followed by benfotiamine daily for two weeks. Total serum antioxidant status (TAS), total oxidant status (TOS) and visfatin levels were measured at the end of the experiment. At the end of the experiment, we investigated both visfatin expression and the histopathology of gastric tissues. The mean visfatin level was lower in the MTX group than in the benfotiamine group. The mean serum TOS levels were higher in MTX group than in the control, benfotiamine or benfotiamine + MTX groups. Significant gastric gland dilation, and erosion and loss of mucosa were found on the gastric surface in the MTX group compared to the control group. The dilation, erosion and mucosal loss were decreased significantly in the benfotiamine + MTX group compared to the MTX group. Compared to the control group, visfatin immunoreactivity was reduced significantly in the MTX group. Decreased visfatin levels appear to play a role in the mechanism of gastric damage. Benfotiamine may be useful for preventing MTX induced gastric injuries.en_US
dc.identifier.doi10.1080/10520295.2020.1853237
dc.identifier.endpage593en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue8en_US
dc.identifier.pmid33325753en_US
dc.identifier.scopus2-s2.0-85097613080en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage586en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2020.1853237
dc.identifier.urihttps://hdl.handle.net/11616/99672
dc.identifier.volume96en_US
dc.identifier.wosWOS:000599357200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenfotiamineen_US
dc.subjectgastric damageen_US
dc.subjectoxidative stressen_US
dc.subjectratsen_US
dc.subjectvisfatinen_US
dc.titleProtective effect of benfotiamine on methotrexate induced gastric damage in ratsen_US
dc.typeArticleen_US

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