Silver(I) N-heterocyclic carbene complexes: Synthesis, characterization and cytotoxic properties

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dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridKızrak, Ümran/0000-0003-1202-9903
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridbasak, nese/0000-0001-5566-8321;
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidKızrak, Ümran/AAA-1538-2021
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidMansour, Lamjed/AAD-8613-2019
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorKaloglu, Nazan
dc.contributor.authorKizrak, Umran
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorTurkmen, Nese Basak
dc.contributor.authorCiftci, Osman
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:48:45Z
dc.date.available2024-08-04T20:48:45Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, sulfonate functionalized N-heterocyclic carbene ligand precursors were obtained from the compounds 1-alkylbenzimidazole, 1,3-propane sultone, and 1,4-butane sultone. These NHC ligand precursors were metallated with Ag2O on moderate conditions to give novel silver-NHC complexes. All new compounds were characterized by by H-1 NMR, C-13 NMR, FT-IR and elemental analysis techniques. The cytotoxic properties of the silver(I) complexes have been assessed in various human cancer lines, including cisplatin-sensitive and resistant cells. IC50 values of these four complexes were determined by the MTT based assay on three human cell lines brain (SHSY5Y) and liver (HEP3B). These silver N-heterocyclic carbene complexes have been highlighted metal-based cancer therapeutic agents with unique structures and functions. These strategies provide exciting opportunities for discovering new types of metallodrugs. (C) 2020 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipKing Saud University, Riyadh, Saudi Arabia [RSP2020/75]; Technological and Scientific Research Council of Turkey [TUB_ITAK-114Z624]en_US
dc.description.sponsorshipThis work was supported by the Research Supporting Project (RSP2020/75), King Saud University, Riyadh, Saudi Arabia and by the Technological and Scientific Research Council of Turkey (TUB_ITAK-114Z624).en_US
dc.identifier.doi10.1016/j.jorganchem.2020.121434
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-85088927383en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2020.121434
dc.identifier.urihttps://hdl.handle.net/11616/99438
dc.identifier.volume923en_US
dc.identifier.wosWOS:000575167700004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectBenzimidazolium saltsen_US
dc.subjectSultoneen_US
dc.subjectSilver-NHC complexesen_US
dc.subjectAntitumor activityen_US
dc.titleSilver(I) N-heterocyclic carbene complexes: Synthesis, characterization and cytotoxic propertiesen_US
dc.typeArticleen_US

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