Prevention of oral mucositis due to 5-fluorouracil treatment with oral cryotherapy

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dc.authoridSevinç, Alper/0000-0002-0499-8918
dc.authorwosidSevinc, Alper/KFQ-6440-2024
dc.authorwosidSevinç, Alper/KPA-4519-2024
dc.contributor.authorBaydar, Mustafa
dc.contributor.authorDikilitas, Mustafa
dc.contributor.authorSevinc, Alper
dc.contributor.authorAydogdu, Ismet
dc.date.accessioned2024-08-04T20:14:54Z
dc.date.available2024-08-04T20:14:54Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: One of the most common and important side effects of 5-fluorouracil (5-FU) is mucositis with ulcerations in the oral cavity. We investigated the effects of local cryotherapy on mucositis incidence administrated during 5-FU treatment. Methods: In a total of 99 courses, 5-FU and folinic acid combination chemotherapy was given to 40 patients. In our study, we considered every course as a single case, and cryotherapy was given to the some patient in one course but not given in the next. Results: While mucositis developed in 6.7% of the courses given with cryotherapy, this ratio was 38.9% in courses given without cryotherapy, In the logistic regression analysis, development of mucositis had been found to correlate only with cryotherapy. Odds ratio (OR)=11.5; in the 95% confidence interval (CI)=3.2-41.9; (p=0.001). Discussion: Results of initial studies evaluating the effects of cryotherapy in preventing mucositis due to 5-FU based chemotherapy regimens were promising. We concluded that oral cooling prevents 5-FU induced mucositis. This effective prophylactic treatment should be used in patients who are at increased risk for developing 5-FU induced mucositis.en_US
dc.identifier.endpage1164en_US
dc.identifier.issn0027-9684
dc.identifier.issn1943-4693
dc.identifier.issue8en_US
dc.identifier.pmid16173332en_US
dc.identifier.scopus2-s2.0-23244458141en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1161en_US
dc.identifier.urihttps://hdl.handle.net/11616/94039
dc.identifier.volume97en_US
dc.identifier.wosWOS:000203403300012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNatl Med Assocen_US
dc.relation.ispartofJournal of The National Medical Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject5-fluorouracilen_US
dc.subjectoral mucositisen_US
dc.subjectcryotherapyen_US
dc.subjectpreventionen_US
dc.titlePrevention of oral mucositis due to 5-fluorouracil treatment with oral cryotherapyen_US
dc.typeArticleen_US

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