Effects of antiepileptic drugs on ovaries of female Wistar rats

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridKARAASLAN, MERVE GOKSIN/0000-0003-2645-808X
dc.authoridOsmanlioglu, Seyma/0000-0003-4963-2685
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidOsmanlıoğlu, Şeyma/JAC-9555-2023
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidOsmanlıoğlu, Şeyma/GXH-7892-2022
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorOsmanlioglu, Seyma
dc.contributor.authorYildiz, Azibe
dc.contributor.authorVardi, Nigar
dc.contributor.authorKaraaslan, Merve
dc.contributor.authorOzhan, Onural
dc.contributor.authorParlakpinar, Hakan
dc.date.accessioned2024-08-04T20:50:26Z
dc.date.available2024-08-04T20:50:26Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractValproate (VPA) induced changes in ovarian morphology are observed in humans with epilepsy and in non-epileptic animals. The effects of lamotrigine (LTG) on female reproduction is not well known. We investigated whether LTG might be a safer drug for use with patients of reproductive age. Forty Wistar albino female rats were divided into five groups. The control group was injected with saline-vehicle solution. The low dose (LD)-VPA group was injected with 100 mg/kg VPA. The high dose (HD)-VPA group was injected with 500 mg/kg VPA. The LD-LTG group was injected with 10 mg/kg LTG. The HD-LTG group was injected with 50 mg/kg LTG. We evaluated histological and biochemical changes in the ovaries. The number of atretic and cystic follicles was increased in the HD-VPA and HD-LTG groups compared to the control group. A significant increase in malondialdehyde level was found in the VPA groups compared to the control and LTG groups. No significant differences in total glutathione levels or superoxide dismutase activity were found among study groups. Catalase activity was significantly higher in HD-VPA and HD-LTG groups compared to the control, LD-VPA and LD-LTG groups. Prevalence and intensity of caspase-3 immunoreactivity in the luteal cells were significantly greater in the HD-LTG group compared to the control group. VPA administration caused polycystic ovarian syndrome-like changes in the ovary. We found that LD-LTG, which reflects the dose for humans, might be a safer option for use during the reproductive age.en_US
dc.identifier.doi10.1080/10520295.2021.1946713
dc.identifier.endpage268en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue4en_US
dc.identifier.pmid34281441en_US
dc.identifier.scopus2-s2.0-85111013681en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage261en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1946713
dc.identifier.urihttps://hdl.handle.net/11616/100060
dc.identifier.volume97en_US
dc.identifier.wosWOS:000675120400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-epileptic drugen_US
dc.subjectlamotrigineen_US
dc.subjectovaryen_US
dc.subjectraten_US
dc.subjectvalproateen_US
dc.titleEffects of antiepileptic drugs on ovaries of female Wistar ratsen_US
dc.typeArticleen_US

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