The Protective Effect of Apocynin on Testicular Ischemia-Reperfusion Injury

Basit Öğe Kaydı
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridyoldas, zeynep rumeysa/0000-0002-5608-9003
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidaltintas, ramazan/AAP-2348-2020
dc.authorwosidÖzbek, Özge/HKW-0623-2023
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.contributor.authorOzbek, Ozkan
dc.contributor.authorAltintas, Ramazan
dc.contributor.authorPolat, Alaaddin
dc.contributor.authorVardi, Nigar
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorSagir, Mustafa
dc.contributor.authorDuran, Zeynep Rumeysa
dc.date.accessioned2024-08-04T20:40:09Z
dc.date.available2024-08-04T20:40:09Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: We investigated the protective effect of the NADPH oxidase inhibitor apocynin on testicular damage induced by ischemia-reperfusion injury in rats. Materials and Methods: A total of 32 rats were randomly divided into 4 groups. Controls underwent left scrotal exploration only. The 3 groups with ischemia-reperfusion underwent 4-hour torsion followed by 1-hour detorsion. The ischemia-reperfusion only group underwent left testicular torsion and detorsion. The ischemia-reperfusion plus saline group underwent left testicular torsion, received 10 ml/kg saline intraperitoneally at minute 210 of ischemia and then underwent detorsion. The ischemia-reperfusion plus apocynin group underwent left testicular torsion, received 20 mg/kg apocynin intraperitoneally at minute 210 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses. Results: In the ischemia-reperfusion only and the ischemia-reperfusion plus saline groups malondialdehyde, total oxidative capacity and the oxidative stress index were significantly higher. Superoxide dismutase, catalase, glutathione peroxidase and glutathione were significantly lower. Apocynin significantly decreased malondialdehyde, total oxidative capacity and the oxidative stress index, and significantly increased superoxide dismutase and catalase. There was a significantly increase in the number of giant, degenerated and desquamated cells in the ischemia-reperfusion group. Apocynin significantly improved these histological alterations. Conclusions: These histopathological and biochemical findings show the beneficial effects of apocynin on testicular ischemia-reperfusion injury.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Uniten_US
dc.description.sponsorshipSupported by the Inonu University Scientific Research Projects Coordination Unit.en_US
dc.identifier.doi10.1016/j.juro.2014.11.086
dc.identifier.endpage1422en_US
dc.identifier.issn0022-5347
dc.identifier.issn1527-3792
dc.identifier.issue4en_US
dc.identifier.pmid25464001en_US
dc.identifier.scopus2-s2.0-84926420706en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1417en_US
dc.identifier.urihttps://doi.org/10.1016/j.juro.2014.11.086
dc.identifier.urihttps://hdl.handle.net/11616/96739
dc.identifier.volume193en_US
dc.identifier.wosWOS:000352102900113en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttestisen_US
dc.subjectspermatic cord torsionen_US
dc.subjectreperfusion injuryen_US
dc.subjectacetovanilloneen_US
dc.subjectantioxidantsen_US
dc.titleThe Protective Effect of Apocynin on Testicular Ischemia-Reperfusion Injuryen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu