Screening of phenolic components and antimicrobial properties of Iris persica L. subsp. persica extracts by in vitro and in silico methods

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dc.authoridUnver, Tuba/0000-0002-8655-2716
dc.authoridUSLU, HARUN/0000-0001-8827-8557
dc.authoridGÖKTAŞ, BÜNYAMİN/0000-0003-2345-7313
dc.authorwosidUnver, Tuba/ABI-6440-2020
dc.authorwosidUSLU, HARUN/P-3681-2019
dc.authorwosidGÖKTAŞ, BÜNYAMİN/HLQ-1238-2023
dc.contributor.authorUnver, Tuba
dc.contributor.authorUslu, Harun
dc.contributor.authorGurhan, Ismet
dc.contributor.authorGoktas, Bunyamin
dc.date.accessioned2024-08-04T20:56:08Z
dc.date.available2024-08-04T20:56:08Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe tendency toward natural herbal products has increased due to the antibiotic resistance developed by microorganisms and the severe side effects of antibiotics commonly used in infectious diseases worldwide. Although antimicrobial studies have been conducted with several species of the Iris genus, this study is the first in the literature to be performed with Iris persica L. subsp. persica aqueous and methanol extracts. In this study, the phenolic content of I. persica was determined by LC-MS/MS analysis, the in vitro antimicrobial activity of I. persica aqueous and methanol extracts was examined, and this study was supported by in silico analysis. Consequently, methanol and aqueous extracts were observed to have inhibitory effects against all tested microorganisms except Candida krusei. Although the MIC values of aqueous extract and methanol extract against Staphylococcus aureus and Klebsiella pneumoniae are the same (22.5 and 11.25 mg/mL, respectively), the inhibitory effect of aqueous extract is generally more potent (MIC value is 11.25 mg/mL for Candida parapsilosis and other bacterial species, and 90 mg/mL for Candida albicans and Candida tropicalis) than that of methanol extract. In silico results showed that hydroxybenzaldeyde, vanillin, resveratrol, isoquercitrin, kaempferol-3-glucoside, fisetin, and luteolin were more prone to antifungal activity. Hence, shikimic, gallic, protocatechuic, vanillic, caffeic, o-coumaric, trans-ferulic, sinapic acids, and hesperidin were more prone to antibacterial activity. In vitro and in silico results show that the antibacterial activity of our extracts may be higher than the antifungal activity. This preliminary study indicates the anti-infective potential of I. persica extracts and their usability in medicine and pharmacology.en_US
dc.identifier.doi10.1002/fsn3.4251
dc.identifier.issn2048-7177
dc.identifier.scopus2-s2.0-85196910235en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/fsn3.4251
dc.identifier.urihttps://hdl.handle.net/11616/102081
dc.identifier.wosWOS:001254010100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFood Science & Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantimicrobial activityen_US
dc.subjectherbal medicineen_US
dc.subjectIris persicaen_US
dc.subjectmolecular dockingen_US
dc.subjectphenolic contentsen_US
dc.titleScreening of phenolic components and antimicrobial properties of Iris persica L. subsp. persica extracts by in vitro and in silico methodsen_US
dc.typeArticleen_US

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