Vascular endothelial function in patients with slow coronary flow

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dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridSigirci, Ahmet/0000-0001-9221-0002
dc.authorwosidErmis, Necip/A-5184-2018
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidKutlusoy, Ergun/ABB-9017-2020
dc.authorwosidErmis, Necip/HJP-7061-2023
dc.authorwosidSigirci, Ahmet/ABG-7387-2020
dc.contributor.authorSezgin, AT
dc.contributor.authorSigirci, A
dc.contributor.authorBarutcu, I
dc.contributor.authorTopal, E
dc.contributor.authorSezgin, N
dc.contributor.authorOzdemir, R
dc.contributor.authorYetkin, E
dc.date.accessioned2024-08-04T20:13:21Z
dc.date.available2024-08-04T20:13:21Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Slow coronary flow (SCF) in a normal coronary angiogram is a well-recognized clinical entity, but its etiopathogenesis remains unclear. Design The aim of the study was to determine endothelial function in patients with SCF using a flow-mediated dilatation (FMD) technique in the brachial artery. Methods Coronary flow was quantified using the corrected thrombosis in myocardial infarction (TIMI) frame count (CTFC) method. Endothelial function was studied in 27 patients with SCF (23 men, four women, mean age 476 8.7 years) and in 30 people with normal coronary flow (NCF) (22 men and eight women, mean age 475 74 years). Results The flow-mediated diameter increase in the SCF group was significantly smaller than that in the NCF group (3.48 +/- 0.10% compared with 9.11 +/- 0.10%, P < 0.001). The percentage of nitroglycerine (NTG)-induced dilatation was not significantly different between patients with SCF and people with NCF (16.8 +/- 1.1% compared with 171 +/- 1.1%, P = 0.87). Simple regression analysis showed that mean CTFC (CTFCm) was strongly and inversely related to the percentage of FMD (r = -0.29, P < 0.01) in all participants. When the patients with SCIF were excluded, CTFC, was still inversely related to the percentage of FMD (r = -0.36, P < 0.05). CTFC, was also inversely related to NTG-induced dilatation in the 57 participants (r = -0.23, P < 0.05). Multiple regression analysis showed that CTFC, was inversely related to the percentage of FMD only (r = -0.37, P < 0.05). Conclusions These findings suggest that endothelial function is impaired in people with SCF and that CTFC correlates well with endothelial dysfunction.en_US
dc.identifier.doi10.1097/00019501-200304000-00008
dc.identifier.endpage161en_US
dc.identifier.issn0954-6928
dc.identifier.issn1473-5830
dc.identifier.issue2en_US
dc.identifier.pmid12655279en_US
dc.identifier.scopus2-s2.0-0038746683en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage155en_US
dc.identifier.urihttps://doi.org/10.1097/00019501-200304000-00008
dc.identifier.urihttps://hdl.handle.net/11616/93570
dc.identifier.volume14en_US
dc.identifier.wosWOS:000182737800008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCoronary Artery Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectendotheliumen_US
dc.subjectblood flowen_US
dc.subjectvasodilatationen_US
dc.titleVascular endothelial function in patients with slow coronary flowen_US
dc.typeArticleen_US

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